Title:
ＦＶＩＩＩの特定部位の変更
Document Type and Number:
Japanese Patent JP6487895
Kind Code:
B2
Abstract:
This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties.
Inventors:
Clark kiew bread
Ji-yong Yi Meh-Fee
Bay Song May
Jyonathan S Strauss
Hendri Tsandra
Jiangmin Chien
Thomas Barnett
Liang Tongue
Dekian Wang
Ji-yong Yi Meh-Fee
Bay Song May
Jyonathan S Strauss
Hendri Tsandra
Jiangmin Chien
Thomas Barnett
Liang Tongue
Dekian Wang
Application Number:
JP2016234756A
Publication Date:
March 20, 2019
Filing Date:
December 02, 2016
Export Citation:
Assignee:
Bayer HealthCare LLC
International Classes:
C07K14/755; A61K38/43; A61K47/34; A61K47/60; A61P7/04; C07K17/08
Domestic Patent References:
| JP11513378A | ||||
| JP2006519238A | ||||
| JP59172425A |
Attorney, Agent or Firm:
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yoshie Sakurada
Yousuke Kawasaki
Takuya Gomibuchi
Toshikazu Imato
Yoshikazu Iwase
Yasufumi Shiroyama
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yoshie Sakurada
Yousuke Kawasaki
Takuya Gomibuchi
Toshikazu Imato
Yoshikazu Iwase
Yasufumi Shiroyama