Title:
プラズモニックチップおよびそれを用いるがん疾病の蛍光画像ならびにラマン分光による診断方法
Document Type and Number:
Japanese Patent JP6492066
Kind Code:
B2
Abstract:
[Problem] To provide: a plasmonic substrate; a method for observing fluorescent image of a candor related substance and a method for Raman spectroscopic analysis using the plasmonic substrate. [Solution] In the present invention, a cancer-related substance in blood or a biological sample can be detected in a selective manner, so it becomes possible to determine the occurrence of cancer by observation of fluorescent image of a crystal of the censor related substance or a coagulated state of the crystal on a plasmonic chip. In addition, the state of chemical modification of a histone tail can be determined by a Raman spectrum analysis, so that it becomes possible to detect occurrence of cancer at an earlier stage and to determine stages of progress of cancer. Furthermore, the location of the cancer-related substance aggregated on a substrate cannot be determined with naked eyes. Then, as a second aspect of the present invention, a method for diagnosing a cancer disease is provided, said method being characterized by firstly identifying the location of the region of a crystal by observing fluorescent image on a microscope, and then irradiating the crystal, with laser beam to analyze with respect to the chemical modification of a histone tail and a remodeling factor.
Inventors:
Yuuki Hasegawa
Katsuyuki Hasegawa
Katsuyuki Hasegawa
Application Number:
JP2016517920A
Publication Date:
March 27, 2019
Filing Date:
May 07, 2015
Export Citation:
Assignee:
Mitec Co., Ltd.
International Classes:
G01N21/64; G01N21/65
Domestic Patent References:
| JP2014238382A | ||||
| JP6457935B2 | ||||
| JP2010537155A |
Foreign References:
| WO2014181814A1 | ||||
| WO2014181816A1 | ||||
| WO2013065747A1 | ||||
| US20110275061 |
Other References:
ITO,Hiroaki,Use of surface-enhanced Raman scattering for detection of cancer-related serum-constituents in gastrointestinal cancer patients,Nanomedicine: Nanotechnology, Biology and Medicine,2013年10月,10/3,599-608
Attorney, Agent or Firm:
Hisao Ishii