Title:
疼痛に対して多重モードの活性を有するピペリジン化合物
Document Type and Number:
Japanese Patent JP6498672
Kind Code:
B2
Abstract:
The present invention relates to compounds having dual pharmacological activity towards both the sigma (σ) receptor, and the μ-opiod receptor and more particularly to piperidene compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
Inventors:
Cuevas Cordobes, Felix
Almansa-Rosales, Carmen
Ayette Garcella, Eva Maria
Serafini Cabanes, Maria Teresa
Garcia Lopez, Monica
Almansa-Rosales, Carmen
Ayette Garcella, Eva Maria
Serafini Cabanes, Maria Teresa
Garcia Lopez, Monica
Application Number:
JP2016539898A
Publication Date:
April 10, 2019
Filing Date:
December 19, 2014
Export Citation:
Assignee:
ESTEVE PHARMACEUTICALS,S.A.
International Classes:
C07D401/06; A61K31/454; A61K31/4545; A61P25/04; A61P25/06; A61P43/00; C07D401/14
Domestic Patent References:
| JP62205058A | ||||
| JP10501819A | ||||
| JP7025851A | ||||
| JP2005320316A | ||||
| JP2013189395A | ||||
| JP2013513621A |
Foreign References:
| WO2011137331A2 | ||||
| GB2083476A | ||||
| WO2014092104A1 |
Other References:
INEKE VAN WIJNGAARDEN; CHRIS G KRUSE; JAN A M VAN DER HEYDEN ET AL,2-PHENYLPYRROLES AS CONFORMATIONALLY RESTRICTED BENZAMIDE ANALOGS. A NEW CLASS OF POTENTIAL ANTIPSYCHOTICS. 2,JOURNAL OF MEDICINAL CHEMISTRY,1988年10月 1日,VOL:31 NR:10,PAGE(S):1934 - 1940,URL,http://dx.doi.org/10.1021/jm00118a011
MOLPORT-016-607-310 COMPOUND SUMMARY FOR: CID 50963011,[ONLINE],PUBCHEM; NCBI,2011年 3月29日,CID 50963011
Database REGISTRY,2012年,Retrieved from STN international [online] ;retrieved on 12 September 2018; RN 1381620-51-4, 1360321-02-3, 1349582-68-8, 1330279-13-4, 1329612-76-1, 1329612-73-8, 1329569-33-6, 744164-93-0
MOLPORT-016-607-310 COMPOUND SUMMARY FOR: CID 50963011,[ONLINE],PUBCHEM; NCBI,2011年 3月29日,CID 50963011
Database REGISTRY,2012年,Retrieved from STN international [online] ;retrieved on 12 September 2018; RN 1381620-51-4, 1360321-02-3, 1349582-68-8, 1330279-13-4, 1329612-76-1, 1329612-73-8, 1329569-33-6, 744164-93-0
Attorney, Agent or Firm:
Mamoru Ushiki
Tomoyuki Takahashi
Moriya Kataka
Junji Tanaka
Yusuke Kato
Tomoyuki Takahashi
Moriya Kataka
Junji Tanaka
Yusuke Kato