Title:
モノアミンオキシダーゼ阻害剤ならびに前立腺がんを処置および診断するための方法
Document Type and Number:
Japanese Patent JP6502308
Kind Code:
B2
Abstract:
A mechanism of monoamine oxidases (MAOs) driven epithelium-to-mesenchymal transition (EMT) is disclosed. Also disclosed are methods for treating cancer by inhibiting or suppressing MAOs in cancer cells. Novel MAOs inhibitors, such as small molecules, siRNA, shRNA, antisense oligonucleotides, aptamers, decoys, and pharmaceutical compositions useful for treating cancer by disrupting the workings of MAOs are provided. In particular, a class of conjugates formed by covalently conjugating near infrared dye 783, IR-780, and MHI-148 to a MAO inhibitor, such as clorgyline, with and without encapsulation it in a nanoparticle is provided. Other aspects of the invention include methods for forming the nano-conjugates, method for monitoring treatment progress in a cancer patient by monitoring the changes in MAO activity, methods for screening patients who are at risk of cancer or differentiating different forms of cancer by assaying the level and location of MAO activity.
Inventors:
Jean Sea. Sea
Lelan Chun
High Yen E. Jau
Boyan Jason Woo
Bogdan Orenyuk
Lelan Chun
High Yen E. Jau
Boyan Jason Woo
Bogdan Orenyuk
Application Number:
JP2016223869A
Publication Date:
April 17, 2019
Filing Date:
November 17, 2016
Export Citation:
Assignee:
Koninklijke Philips Electronics N.V.
International Classes:
A61K31/137; A61K31/138; A61K31/5375; A61K47/22; A61K47/54; A61P13/08; A61P35/00
Foreign References:
| WO2009152440A1 |
Other References:
J. Cancer Res. Clin. Oncol.,2010年,Vol.136, No.11,p.1761-1771
Clinical Cancer Research,2010年,Vol.16, No.10,p.2833-2844
Clinical Cancer Research,2010年,Vol.16, No.10,p.2833-2844
Attorney, Agent or Firm:
Kurata Masatoshi