Title:
化学架橋剤
Document Type and Number:
Japanese Patent JP6506250
Kind Code:
B2
Abstract:
Disclosed herein are methods of chemical conjugation comprising contacting a lysosomal enzyme with a first crosslinking agent to introduce aldehyde groups; contacting a lysosomal targeting peptide with a second crosslinking agent to introduce a hydrazide group at the N-terminal residue; contacting the lysosomal enzyme with aldehyde groups of step a. with the lysosomal targeting peptide with a hydrazide group at the N-terminal residue of step b; and forming a lysosomal enzyme-lysosomal targeting peptide conjugate.
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Inventors:
Dawn
Application Number:
JP2016502634A
Publication Date:
April 24, 2019
Filing Date:
March 14, 2014
Export Citation:
Assignee:
Amicus Therapeutics, Inc.
International Classes:
C07K1/06; C07K14/65; C12N9/14; C12N9/20; C12N9/24; C12N9/40; C12N9/96
Domestic Patent References:
| JP2004501869A |
Foreign References:
| WO2012166653A1 |
Attorney, Agent or Firm:
Sonoda/Kobayashi Patent Business Corporation