Title:
結晶性ジアシルヒドラジンおよびその使用
Document Type and Number:
Japanese Patent JP6522826
Kind Code:
B2
Abstract:
The present disclosure provides crystalline polymorphic and amorphous forms of (R)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N'-(2-ethyl-3-methoxybenzoyl)-hydrazide (Compound 1) or (S)-3,5-dimethyl-benzoic acid N-(1-tert-butyl-butyl)-N'-(2-ethyl-3-methoxy-benzoyl)-hydrazide (Compound 2). The present disclosure further provides compositions comprising crystalline polymorphic and amorphous forms of Compound 1 or Compound 2 and an excipient, methods of making crystalline polymorphic or amorphous forms of Compound 1 or Compound 2, and methods of using crystalline polymorphic or amorphous forms of Compound 1 or Compound 2 to regulate gene expression in a cell or in a subject.
Inventors:
Hohmann, Robert, Yi.
Charmant, inna
Rodel, Eva
Hilfiker, Rolf
DePaul, Susan, M.
Charmant, inna
Rodel, Eva
Hilfiker, Rolf
DePaul, Susan, M.
Application Number:
JP2018073426A
Publication Date:
May 29, 2019
Filing Date:
April 05, 2018
Export Citation:
Assignee:
Intrexon Corporation
International Classes:
A61K31/166; A61P3/00; A61P7/00; A61P7/06; A61P11/00; A61P13/12; A61P25/00; A61P27/02; A61P29/00; A61P31/00; A61P35/00; A61P37/00; C12N15/24; C12N15/861
Domestic Patent References:
| JP2010531297A | ||||
| JP5155821A |
Other References:
平山令明,有機化合物結晶作製ハンドブック,2008年,p.17-23,37-40,45-51,57-65
高田則幸,創薬段階における原薬Formスクリーニングと選択,PHARM STAGE,2007年 1月15日,Vol.6, No.10,p.20-25
CAIRA, M.R.,Crystalline Polymorphism of Organic Compounds,Topics in Current Chemistry,1998年,No.198,p.163-208
高田則幸,創薬段階における原薬Formスクリーニングと選択,PHARM STAGE,2007年 1月15日,Vol.6, No.10,p.20-25
CAIRA, M.R.,Crystalline Polymorphism of Organic Compounds,Topics in Current Chemistry,1998年,No.198,p.163-208
Attorney, Agent or Firm:
Hiroshi Kobayashi
Norio Omori
Emiko Nishizawa
Yasuhito Suzuki
Norio Omori
Emiko Nishizawa
Yasuhito Suzuki