Title:
抗ＣＧＲＰ組成物およびその使用
Document Type and Number:
Japanese Patent JP6527563
Kind Code:
B2
Abstract:
The present invention is directed to antibodies and fragments thereof having binding specificity for CGRP. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-CGRP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-CGRP antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-CGRP antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with CGRP.
Inventors:
Kovacevich, Brian Robert
Garcia-Martinez, Leon Ef
Olson, Katie
Duzer, Benjamin H
Bill Glenn, Jens Jay
Rutherm, John A
Mitchell, Daniel M
McNeill, Patricia Diane
Janson, Nicole M
Loomis, Maria-Christina
Garcia-Martinez, Leon Ef
Olson, Katie
Duzer, Benjamin H
Bill Glenn, Jens Jay
Rutherm, John A
Mitchell, Daniel M
McNeill, Patricia Diane
Janson, Nicole M
Loomis, Maria-Christina
Application Number:
JP2017160778A
Publication Date:
June 05, 2019
Filing Date:
August 24, 2017
Export Citation:
Assignee:
Alder Bio Holdings LLC
International Classes:
C12N15/13; A61K39/395; A61P25/06; C07K16/26; C12P21/08
Domestic Patent References:
| JP6282584B2 | ||||
| JP2011046710A | ||||
| JP2011513387A | ||||
| JP2011513386A | ||||
| JP6087890A |
Foreign References:
| WO2007076336A1 |
Other References:
British Journal of Pharmacology,2008年,vol.155,pp.1093-1103
Attorney, Agent or Firm:
Shinjiro Ono
Osamu Yamamoto
Toru Miyamae
Motoharu Nakanishi
Hirose Shinobu
Osamu Yamamoto
Toru Miyamae
Motoharu Nakanishi
Hirose Shinobu