Title:
治療活性化合物およびそれらの使用方法
Document Type and Number:
Japanese Patent JP6538037
Kind Code:
B2
Abstract:
Provided are methods for preparing a compound of formula (Ia):Wherein R1-R8 and A are as defined in the claims.
Inventors:
Conteatis Zenon Dee.
Popovich-Muller Janeta
Travins Jeremy M.
Sarah robert
Tsai Zenway
Butterfly tin
Popovich-Muller Janeta
Travins Jeremy M.
Sarah robert
Tsai Zenway
Butterfly tin
Application Number:
JP2016524672A
Publication Date:
July 03, 2019
Filing Date:
July 10, 2014
Export Citation:
Assignee:
Agios Pharmaceuticals, Inc.
International Classes:
C07D251/18; A61K31/506; A61K31/53; A61K31/5377; A61K45/00; A61P35/00; A61P35/02; A61P43/00; C07D401/04; C07D401/14; C07D403/04; C07D403/14; C07D405/14; C07D417/04; C07D417/14
Domestic Patent References:
| JP2005533011A | ||||
| JP2012529511A | ||||
| JP11158073A | ||||
| JP2010513313A | ||||
| JP2011094120A | ||||
| JP2003073363A | ||||
| JP51014928A | ||||
| JP2005501855A | ||||
| JP2010181540A | ||||
| JP2010079130A | ||||
| JP2004107220A | ||||
| JP2009237115A | ||||
| JP2004083610A | ||||
| JP2002053777A | ||||
| JP48076874A | ||||
| JP5140126A | ||||
| JP2005264016A |
Foreign References:
| EP0407899A2 | ||||
| WO1993017009A1 | ||||
| WO2013046136A1 | ||||
| WO2013004332A1 | ||||
| WO2012074999A1 | ||||
| WO2013016206A1 | ||||
| GB1033266A |
Other References:
Ambartsumyan, E. N. et al.,Synthesis and transformations of chloropyrazolylazines,Hayastani Kimiakan Handes,2011年,64(4),pp. 544-550
MIKHAYLICHENKO, S. et al.,Syntheis and structure of new 1,2,3-triazolyl substituted 1,3,5-triazines,European Journal of Chemistry,2012年,3(1),pp. 1-9
DREW, M. G. B. et al.,Solvent extraction and lanthanide complexation studies with new terdentate ligands containing two 1,3,5-triazine moieties,Dalton Transactions,2004年,(2),pp. 244-251
ENHOLM, E. J. et al.,Hydrogen-Bonded Arrays Coupled by Cross-Metathesis,SYNLETT,2008年,(2),pp. 203-206
GEWALD, R. et al.,Discovery of triazines as potent, selective and orally active PDE4 inhibitors,Bioorganic & Medicinal Chemistry Letters,2013年,23,pp. 4308-4314
LEE, J. W. et al.,Combinatorial Solid-Phase Synthesis of 6-Aryl-1,3,5-triazines via Suzuki Coupling,Aust. J. Chem.,2011年,64,pp. 540-544
MIKHAYLICHENKO, S. N. et al.,sym-Triazines.7. Hydrolysis and cyclization of 1,3,5-triazine series mononitriles,Chemistry of Heterocyclic Compounds,2006年,42(5),pp. 642-647
MIKHAYLICHENKO, S. et al.,Syntheis and structure of new 1,2,3-triazolyl substituted 1,3,5-triazines,European Journal of Chemistry,2012年,3(1),pp. 1-9
DREW, M. G. B. et al.,Solvent extraction and lanthanide complexation studies with new terdentate ligands containing two 1,3,5-triazine moieties,Dalton Transactions,2004年,(2),pp. 244-251
ENHOLM, E. J. et al.,Hydrogen-Bonded Arrays Coupled by Cross-Metathesis,SYNLETT,2008年,(2),pp. 203-206
GEWALD, R. et al.,Discovery of triazines as potent, selective and orally active PDE4 inhibitors,Bioorganic & Medicinal Chemistry Letters,2013年,23,pp. 4308-4314
LEE, J. W. et al.,Combinatorial Solid-Phase Synthesis of 6-Aryl-1,3,5-triazines via Suzuki Coupling,Aust. J. Chem.,2011年,64,pp. 540-544
MIKHAYLICHENKO, S. N. et al.,sym-Triazines.7. Hydrolysis and cyclization of 1,3,5-triazine series mononitriles,Chemistry of Heterocyclic Compounds,2006年,42(5),pp. 642-647
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto