Title:
髄膜炎菌（Ｎｅｉｓｓｅｒｉａ ｍｅｎｉｎｇｉｔｉｄｉｓ）組成物およびその方法
Document Type and Number:
Japanese Patent JP6538121
Kind Code:
B2
Abstract:
In one aspect, the invention relates to a composition including a first polypeptide having the sequence set forth in SEQ ID NO: 1 and a second polypeptide having the sequence set forth in SEQ ID NO: 2. In one embodiment, the composition includes about 120 µg/ml of a first polypeptide including the amino acid sequence set forth in SEQ ID NO: 1, 120 µg/ml of a second polypeptide including the amino acid sequence set forth in SEQ ID NO: 2, about 2.8 molar ratio polysorbate-80 to the first polypeptide, about 2.8 molar ratio polysorbate-80 to the second polypeptide, about 0.5 mg/ml aluminum, about 10 mM histidine, and about 150 mM sodium chloride. In one embodiment, a dose of the composition is about 0.5 ml in total volume. In one embodiment, two-doses of the composition induce a bactericidal titer against diverse heterologous subfamily A and subfamily B strains in a human.
Inventors:
Anna Lisa Civil Anderson
Rasappa Gounder Almagham
John Irwin Farley
Rear Diane Fletcher
Shannon Harris
Catherine Ute Jansen
Thomas Richard Jones
Lakshmi Kandoki
Bauson loan
John Lance Perez
Gully Warren Zlotunick
Rasappa Gounder Almagham
John Irwin Farley
Rear Diane Fletcher
Shannon Harris
Catherine Ute Jansen
Thomas Richard Jones
Lakshmi Kandoki
Bauson loan
John Lance Perez
Gully Warren Zlotunick
Application Number:
JP2017135738A
Publication Date:
July 03, 2019
Filing Date:
July 11, 2017
Export Citation:
Assignee:
Pfizer Inc.
International Classes:
A61K38/16; A61K9/08; A61K39/095; A61K47/02; A61K47/22; A61K47/34; A61K47/54; A61P31/04; A61P43/00; C07K14/37
Foreign References:
| WO2012025873A1 | ||||
| WO2012117377A1 |
Attorney, Agent or Firm:
Noh four
Junko Miyazawa
Maki Sato
Tatsuta Miyuki
Rie Ikeda
Junko Miyazawa
Maki Sato
Tatsuta Miyuki
Rie Ikeda