Title:
インスリン様成長因子１受容体特異的抗体及びそれらの使用
Document Type and Number:
Japanese Patent JP6541237
Kind Code:
B2
Abstract:
The blood-brain barrier (BBB) prevents transport of molecules larger than 500 Dal tons from blood to brain. Receptor-mediated transcytosis (RMT) facilitates transport across the BBB of specific molecules that bind receptors on brain endothelial cells that form the BBB. An insulin-like growth factor 1 receptor (IGF 1R)-binding antibody or fragment thereof is identified that transmigrates the BBB by RMT. The antibody or fragment is used to deliver a cargo molecule across the BBB, wherein the cargo molecule may be a therapeutic or detectable agent. The antibody is a camelid VHH, prepared by immunizing a llama with a 933-amino acid IGF 1R polypeptide. Humanized forms of the camelid VHH are also generated.
Inventors:
Stanimirovich, Danica
Kemerick, christine
Hakkani, Alsaran S.
Slair, Trian
Albabi-Galodi, Mahdi
Massey, Bernard
Gilbert, Leonard
Kemerick, christine
Hakkani, Alsaran S.
Slair, Trian
Albabi-Galodi, Mahdi
Massey, Bernard
Gilbert, Leonard
Application Number:
JP2016555727A
Publication Date:
July 10, 2019
Filing Date:
December 04, 2014
Export Citation:
Assignee:
NATIONAL RESEARCH COUNCIL OF CANADA
International Classes:
C12N15/13; A61K39/395; A61K47/46; A61K47/50; A61K49/00; A61P25/00; A61P25/16; A61P25/28; C07K16/28; G01N33/53
Domestic Patent References:
| JP2013534811A | ||||
| JP2009511032A | ||||
| JP2006511516A |
Foreign References:
| US20050085419 |
Other References:
PLOS ONE,2012年,Vol.7, No.8, e44235,p.1-14
Biotechnol Bioeng,2013年,Vol.110, No.5,p.1456-1465
Neuron,2014年 1月 8日,Vol.81,p.49-60
Biotechnol Bioeng,2013年,Vol.110, No.5,p.1456-1465
Neuron,2014年 1月 8日,Vol.81,p.49-60
Attorney, Agent or Firm:
Ikeda adult
Junichiro Sakamaki
Masakazu Noda
Kazuhiro Yamaguchi
Junichiro Sakamaki
Masakazu Noda
Kazuhiro Yamaguchi