Title:
三環式化合物、及び癌治療におけるそれらの使用
Document Type and Number:
Japanese Patent JP6545908
Kind Code:
B2
Abstract:
There is provided compounds of formula (I), or pharmaceutically-acceptable salts thereof, wherein X, Y, Z, R1 and R2 have meanings provided in the description, which compounds are useful in the treatment of cancers.
Inventors:
Elias Set Jene Anérère
William Chester Stafford
Nathan Patrick Cousense
Diane Karen Lucy
David Joseph Maloney
Anton Simeonoff
Agit Jadav
Thomas S. Dexheimer
William Chester Stafford
Nathan Patrick Cousense
Diane Karen Lucy
David Joseph Maloney
Anton Simeonoff
Agit Jadav
Thomas S. Dexheimer
Application Number:
JP2018526610A
Publication Date:
July 17, 2019
Filing Date:
August 05, 2016
Export Citation:
Assignee:
Elias Set Jene Anérère
The United States of America as Representatives by the Secretary for the Department of Health and Human Services
The United States of America as Representatives by the Secretary for the Department of Health and Human Services
International Classes:
C07D471/18; A61K31/439; A61K31/4545; A61K31/5377; A61K45/00; A61P35/00; A61P35/02; A61P43/00
Other References:
Malinakova, Helena C.; Liebeskind, Lanny S.,Enantiocontrolled Synthesis of Highly Functionalized Tropanes via [5+2] Cycloaddition to η3-Pyridinylmolybdenum π-Complexes,Organic Letters,2000年,2(24),3909-3911
El-Abbady, S. A.; Abdel-Hamid, H. A.; Shalaby, A. A.; Ahmed, M. G.; Moustafa, A. H.,[4N + 2]π Cycloadditions of 1-(6-arylpyridazin-3-yl)-3-oxidopyridinium betaines with 2π 1,3-dipolarophiles,Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry,1989年,28B(11),923-7
Katritzky, Alan R. etal.,1,3-Dipolar character of six-membered aromatic rings. Part 51. Cycloadditions of 1-(β-benzoylvinyl)-3-oxidopyridiniums and subsequent transformations,Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999),1980年,(2),362-71
Fielding, M. R.; Grigg, R.; Sridharan, V.; Thornton-Pett, M.; Urch, C. J.,Sequential oxopyridinium betaine cycloaddition-palladium catalyzed cyclization-anion capture processes,Tetrahedron,2001年,57(36),7737-7748
El-Abbady, S. A.; Abdel-Hamid, H. A.; Shalaby, A. A.; Ahmed, M. G.; Moustafa, A. H.,[4N + 2]π Cycloadditions of 1-(6-arylpyridazin-3-yl)-3-oxidopyridinium betaines with 2π 1,3-dipolarophiles,Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry,1989年,28B(11),923-7
Katritzky, Alan R. etal.,1,3-Dipolar character of six-membered aromatic rings. Part 51. Cycloadditions of 1-(β-benzoylvinyl)-3-oxidopyridiniums and subsequent transformations,Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999),1980年,(2),362-71
Fielding, M. R.; Grigg, R.; Sridharan, V.; Thornton-Pett, M.; Urch, C. J.,Sequential oxopyridinium betaine cycloaddition-palladium catalyzed cyclization-anion capture processes,Tetrahedron,2001年,57(36),7737-7748
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mitsuhiro
Tatsuhiko Abe
Shinya Mitsuhiro
Tatsuhiko Abe