Title:
単一サイクルでコンディショニングおよび化学選択を組み合わせる方法
Document Type and Number:
Japanese Patent JP6560332
Kind Code:
B2
Abstract:
A method of radiation-free hematopoietic stem cell (HSC) transplantation comprises administering to a mammalian subject one or two doses of 2 to 10 mg/kg body weight of a purine base analog, such as 6TG as a pre-conditioning step. The method further comprises engrafting into the subject hypoxanthine-guanine phosphoribosyltransferase (HPRT)-deficient donor HSCs within 48 to 72 hours of the pre-conditioning step; and administering to the subject about 1 to 5 mg/kg of the purine base analog every two to four days for two to eight weeks following the engrafting step. The method is performed in the absence of pre-conditioning via radiation. The subject is therefore not treated with myeloablative radiation in preparation for transplantation, and thus the subject is free of myeloablative radiation-induced toxicity.
Inventors:
Noriyuki Kasahara
Thistle Robert H.
Hacke Katrine
Shark Mary Acos
Crooks Guy M.
Thistle Robert H.
Hacke Katrine
Shark Mary Acos
Crooks Guy M.
Application Number:
JP2017243476A
Publication Date:
August 14, 2019
Filing Date:
December 20, 2017
Export Citation:
Assignee:
The Regents of The University of California
International Classes:
A61K35/28; A61K31/52; A61P7/00; A61P7/04; A61P7/06; A61P31/18; A61P35/02
Domestic Patent References:
| JP5997257B2 |
Foreign References:
| US20030032003 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto