Title:
色素沈着過剰状態の遺伝子発現シグネチャーを生成する方法
Document Type and Number:
Japanese Patent JP6563889
Kind Code:
B2
Abstract:
A method of generating a hyperpigmentation condition gene expression signature for use in identifying connections between perturbagens and genes associated with a skin pigmentation condition. The method includes providing a gene expression profile for a reference sample of human skin cells not affected with a pigmentation condition; generating a gene expression profile for a sample of human skin cells from a subject exhibiting the hyperpigmentation condition; comparing the expression profiles to determine a gene expression signature that includes a set of differentially expressed genes; assigning an identifier to each gene constituting the gene expression signature and ordering the identifiers according to the direction of differential expression to create one or more gene expression signature lists; and storing the one or more gene expression signature lists on at least one computer readable medium.
More Like This:
Inventors:
Tomohiro Hakozaki
Wenju Jiao
Robert Lloyd Binder
Jun Shu
Wenju Jiao
Robert Lloyd Binder
Jun Shu
Application Number:
JP2016251821A
Publication Date:
August 21, 2019
Filing Date:
December 26, 2016
Export Citation:
Assignee:
THE PROCTER & GAMBLE COMPANY
International Classes:
C12Q1/6809; G16B20/20; C12Q1/6813; G16B25/10
Domestic Patent References:
| JP2012044874A |
Foreign References:
| WO2012011904A1 |
Other References:
LAMB J. et al.,"The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.",SCIENCE,2006年 9月29日,Vol.313,pp.1929-1935
BISSETT, D.L. et al.,"GENOMIC EXPRESSION CHANGES INDUCED BY TOPICAL N-ACETYL GLUCOSAMINE IN SKIN EQUIVALENT CULTURES IN VITRO.",JOURNAL OF COSMETIC DERMATOLOGY,2007年12月,Vol.6, No.4,pp.232-238
BERNARD, F.X. et al.,"Comparison of gene expression profiles in human keratinocyte mono-layer cultures, reconstituted epidermis and normal human skin; transcriptional effects of retinoid treatments in reconstituted human epidermis.",EXPERIMENTAL DERMATOLOGY,2002年 2月,Vol.11, No.1,pp.59-74
AOKI, H. et al.,"Gene expression profiling analysis of solar lentigo in relation to immunohistochemical characteristics.",BR. J. DERMATOL.,2007年 6月,Vol.156, No.6,pp.1214-1223
BISSETT, D.L. et al.,"GENOMIC EXPRESSION CHANGES INDUCED BY TOPICAL N-ACETYL GLUCOSAMINE IN SKIN EQUIVALENT CULTURES IN VITRO.",JOURNAL OF COSMETIC DERMATOLOGY,2007年12月,Vol.6, No.4,pp.232-238
BERNARD, F.X. et al.,"Comparison of gene expression profiles in human keratinocyte mono-layer cultures, reconstituted epidermis and normal human skin; transcriptional effects of retinoid treatments in reconstituted human epidermis.",EXPERIMENTAL DERMATOLOGY,2002年 2月,Vol.11, No.1,pp.59-74
AOKI, H. et al.,"Gene expression profiling analysis of solar lentigo in relation to immunohistochemical characteristics.",BR. J. DERMATOL.,2007年 6月,Vol.156, No.6,pp.1214-1223
Attorney, Agent or Firm:
Patent Business Corporation Tani/Abe Patent Office