Title:
単一のｓｉＲＮＡおよびｓｈＲＮＡナノカプセルに基づいた新規ＲＮＡｉ分子送達プラットホーム
Document Type and Number:
Japanese Patent JP6571220
Kind Code:
B2
Abstract:
Novel siRNA and shRNA nanocapsules and delivery methods are disclosed herein. These siRNA and shRNA nanocapsules and delivery methods are highly robust and effective. This invention provides a platform for RNAi delivery with low toxicity and long intracellular half-life for practical therapeutic applications.
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Inventors:
Yang, Min
Liang, Min
Chen, Irvine, S. Wai.
Kamata, Masakaz
Wen, gin
Le, Yun Feng
Liang, Min
Chen, Irvine, S. Wai.
Kamata, Masakaz
Wen, gin
Le, Yun Feng
Application Number:
JP2018012382A
Publication Date:
September 04, 2019
Filing Date:
January 29, 2018
Export Citation:
Assignee:
The Regents of The University of California
International Classes:
A61K9/51; A61K31/713; A61K47/32; A61K48/00; A61P35/00
Domestic Patent References:
| JP6283652B2 | ||||
| JP2010163364A |
Other References:
Nature Nanotechnology,2010年 1月,Vol.5,p.48-53,DOI:10.1038/NNANO.2009.341
Journal of Controlled Release,2010年,Vol.144,p.251-258
The AAPS Journal,2010年12月,Vol.12,No.4,p.492-503,DOI:10.1208/s12248-010-9210-4
Nucleic Acid Therapeutics,2011年,Vol.21,No.3,p.133-147
Expert Opin. Drug Deliv.,2011年,Vol.8, No.4,p.521-536
Journal of Controlled Release,2010年,Vol.144,p.251-258
The AAPS Journal,2010年12月,Vol.12,No.4,p.492-503,DOI:10.1208/s12248-010-9210-4
Nucleic Acid Therapeutics,2011年,Vol.21,No.3,p.133-147
Expert Opin. Drug Deliv.,2011年,Vol.8, No.4,p.521-536
Attorney, Agent or Firm:
Yoshiyuki Inaba
Toshifumi Onuki
Akihiko Eguchi
Kazuhiko Naito
Toshifumi Onuki
Akihiko Eguchi
Kazuhiko Naito