Title:
ＮＡＶ チャンネル阻害剤としてのヘテロ環化合物及びその使用
Document Type and Number:
Japanese Patent JP6577479
Kind Code:
B2
Abstract:
The present invention relates to heterocyclic compounds, and pharmaceutically acceptable compositions thereof, useful as Nav1.6 inhibitors.
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Inventors:
Brian sheller
Nadia brugger
Nadia brugger
Application Number:
JP2016554329A
Publication Date:
September 18, 2019
Filing Date:
February 26, 2015
Export Citation:
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
International Classes:
C07D207/16; A61K31/40; A61K31/4178; A61K31/4439; A61P21/02; A61P25/00; A61P25/16; A61P25/28; C07D401/12; C07D403/12; C07D405/12; C07D409/12
Domestic Patent References:
| JP2011507908A | ||||
| JP6507149A | ||||
| JP2006517948A | ||||
| JP2006522119A | ||||
| JP2013517283A | ||||
| JP2012529476A |
Foreign References:
| WO1993016077A1 | ||||
| KR1020130096900A | ||||
| WO2008156580A1 | ||||
| WO2008045564A1 | ||||
| WO2013149704A1 | ||||
| WO2013088191A1 | ||||
| CN102153544A | ||||
| WO2009076404A1 |
Other References:
EINSIEDEL J,PHENYLOXAZOLES AND PHENYLTHIAZOLES AS BENZAMIDE BIOISOSTERES: SYNTHESIS 以下備考,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,NL,PERGAMON,2000年 9月 1日,VOL:10, NR:17,PAGE(S):2041 - 2044,AND DOPAMINE RECEPTOR BINDING PROFILES,URL,http://www.sciencedirect.com/science/article/pii/S0960894X00004054
Bioorganic & Medicinal Chemistry Letters,2013年,23,pp.4388-4392
Bioorganic & Medicinal Chemistry Letters,2011年,21,pp.3095-3098
J. Med. Chem.,1990年,33(2),pp.849-854
ANNAMARIA DE LUCA,SEARCHING FOR NOVEL ANTI-MYOTONIC AGENTS: PHARMACOPHORE REQUIREMENT FOR USE-DEPENDENT 以下備考,NEUROMUSCULAR DISORDERS,英国,PERGAMON PRESS,2011年 7月 4日,VOL:22, NR:1,PAGE(S):56 - 65,BLOCK OF SKELETAL MUSCLE SODIUM CHANNELS BY-BENZYLATED CYCLIC DERIVATIVES OF TOCAINIDE,URL,http://dx.doi.org/10.1016/j.nmd.2011.07.001
Bioorganic & Medicinal Chemistry Letters,2013年,23,pp.4388-4392
Bioorganic & Medicinal Chemistry Letters,2011年,21,pp.3095-3098
J. Med. Chem.,1990年,33(2),pp.849-854
ANNAMARIA DE LUCA,SEARCHING FOR NOVEL ANTI-MYOTONIC AGENTS: PHARMACOPHORE REQUIREMENT FOR USE-DEPENDENT 以下備考,NEUROMUSCULAR DISORDERS,英国,PERGAMON PRESS,2011年 7月 4日,VOL:22, NR:1,PAGE(S):56 - 65,BLOCK OF SKELETAL MUSCLE SODIUM CHANNELS BY-BENZYLATED CYCLIC DERIVATIVES OF TOCAINIDE,URL,http://dx.doi.org/10.1016/j.nmd.2011.07.001
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Ryotaro Takei
Takahide Sasaki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Ryotaro Takei
Takahide Sasaki
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