Title:
人工核酸分子
Document Type and Number:
Japanese Patent JP6584414
Kind Code:
B2
Abstract:
The invention relates to an artificial nucleic acid molecule comprising at least one open reading frame and at least one 3′-untranslated region element (3′-UTR element) comprising a nucleic acid sequence which is derived from the 3′-UTR of a FIG4 gene or from a variant of the 3′-UTR of a FIG4 gene. The invention further relates to the use of such an artificial nucleic acid molecule in gene therapy and/or genetic vaccination. Furthermore, the invention relates to the use of a 3′-UTR element comprising a nucleic acid sequence which is derived from the 3′-UTR of a FIG4 gene or from a variant of the 3′-UTR of a FIG4 gene for the stabilization and/or prolongation of protein expression from a nucleic acid sequence comprising such 3′-UTR element.
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Inventors:
Stephanie Grund
Thomas Shurake
Thomas Shurake
Application Number:
JP2016543567A
Publication Date:
October 02, 2019
Filing Date:
December 30, 2014
Export Citation:
Assignee:
Cure Back Age
International Classes:
C12N15/67; A61K31/7088; A61K31/7105; A61K35/76; A61K39/00; A61K48/00; A61P35/00; A61P37/04; C12N5/10
Foreign References:
| WO2008112127A1 | ||||
| WO2013120629A1 | ||||
| WO2013143698A1 |
Attorney, Agent or Firm:
Koichi Hirota
Yoshihiro Nagare
Naoko Matsuda
Yoshihiro Nagare
Naoko Matsuda