Title:
免疫毒素およびチェックポイント阻害剤の併用療法
Document Type and Number:
Japanese Patent JP6587756
Kind Code:
B2
Abstract:
Regional, tumor-targeted, cytotoxic therapy, such as D2C7-immunotoxin (D2C7-IT), not only specifically target and destroy tumor cells, but in the process initiate immune events that promote an in situ vaccine effect. The antitumor effects are amplified by immune checkpoint blockade which engenders a long-term systemic immune response that effectively eliminates all tumor cells.
Inventors:
Bigner darrel
Chandra Mohan Vidya Lakshmi
Nier Sumita
Gromey Matthias
Bao Shuhui
Pastan Islay H.
Chandra Mohan Vidya Lakshmi
Nier Sumita
Gromey Matthias
Bao Shuhui
Pastan Islay H.
Application Number:
JP2018543049A
Publication Date:
October 09, 2019
Filing Date:
November 04, 2016
Export Citation:
Assignee:
DUKE UNIVERSITY
The Government of the United States as Represented by the Secretary of Health and Human Services National Institute of Health
The Government of the United States as Represented by the Secretary of Health and Human Services National Institute of Health
International Classes:
A61K47/68; A61K31/4439; A61K38/02; A61K39/395; A61K47/66; A61P11/00; A61P15/00; A61P17/00; A61P25/00; A61P35/00; A61P43/00
Domestic Patent References:
| JP2014513136A | ||||
| JP2006521377A | ||||
| JP2012533619A | ||||
| JP2013529183A |
Foreign References:
| WO2015069770A1 | ||||
| US20090269343 | ||||
| WO2015138920A1 | ||||
| WO2015117002A1 | ||||
| WO2015112900A1 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto