ＨＬＡをコードする遺伝子のヌクレアーゼ媒介編集により作製される免疫適合性細胞

Japanese Patent JP6598860

B2

The present invention relates to a method for producing immune-compatible cells or a cell population which comprises a step of editing one or two alleles of one or more immune-compatible antigen genes by gene deletion or modification in an isolated cell comprising at least one of the immune-compatible antigen genes selected from HLA (human leukocyte antigen)-A, HLA-B and HLA-DR, to immune-compatible cells produced by the method, and to a cell population comprising the immune-compatible cells produced by the method.

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Kim, Jin Su
Hwang, Don Youn

JP2017527526A

October 30, 2019

August 06, 2015

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College of Medicine Pocheoncha University Industry-Academic Co-Operation Foundation

C12N15/09; C12N5/10

WO2007047894A1

BLOOD, 2013, Vol.122, p.1341-1349
Develop.Growth Differ., 2014 Jan, Vol.56, p.2-13
THE JOURNAL OF BIOLOGICAL CHEMISTRY, 2014 Feb., Vol.289, p.4594-4599
PNAS, 2014 June, Vol.111, p.9253-9258

Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Naoko Kikuta
Satoko Tsuruta

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