Title:
外用医薬組成物
Document Type and Number:
Japanese Patent JP6599083
Kind Code:
B2
Abstract:
[Problem] The objective of the present invention is to provide a preparation technique with which yellowing that occurs over time or in high-temperature conditions can be suppressed and excellent storage stability can be provided even when diclofenac and/or a salt thereof and a tocopherol and/or derivative thereof are included in a pharmaceutical composition for external use that includes water. [Solution] Provided is a pharmaceutical composition for external use that includes diclofenac and/or a salt thereof, a tocopherol and/or derivative thereof, and water, wherein by mixing in lactic acid and/or a salt thereof, yellowing that occurs over time or in high-temperature conditions can be suppressed, and excellent storage stability can be provided.
Inventors:
Aka Katsu
Kozue Imai
Kozue Imai
Application Number:
JP2014070677A
Publication Date:
October 30, 2019
Filing Date:
March 30, 2014
Export Citation:
Assignee:
KOBAYASHI PHARMACEUTICAL CO.,LTD.
International Classes:
A61K31/196; A61K9/08; A61K31/355; A61K47/10; A61K47/12; A61P29/00; A61P43/00
Domestic Patent References:
| JP2005336063A | ||||
| JP6048939A | ||||
| JP2008517935A | ||||
| JP11255644A | ||||
| JP2004115525A |
Foreign References:
| CH699814A3 | ||||
| WO1992007561A1 | ||||
| WO2013036961A1 |
Other References:
Dr. H. Bartsch,Ergebnis und Auswertung einer Doppelblind-Studie mit Vitamin E und Diclofenac-Natrium sowie der Komb,Fat Science Technology,1990年,92(5),197-201
Attorney, Agent or Firm:
Junya Tanaka