共有結合で連結されたヘリカー−抗ヘリカー抗体コンジュゲートおよびその用途

Japanese Patent JP6602304

B2

Herein is reported a conjugate comprising a helicar motif amino acid sequence containing compound and an antibody that specifically binds to the helicar motif amino acid sequence characterized by a covalent bond between the helicar motif amino acid sequence containing compound and an amino acid residue in the CDR2 of the anti-helicar antibody, whereby the CDR2 is determined according to Kabat.

JPH06506826	[Title of Invention] Proteinic lipid-containing particles
JP5221710	Polypeptides with cellulose degradation enhancing activity and polynucleotides encoding them
WO/1990/008162	SYNTHETIC PEPTIDE COMPOSITIONS WITH IMMUNOREACTIVITIES TO ANTIBODIES TO HTLV-1

Brinkmann Urich
Georges gui
Hoffman Aike
Tea Fentaler Georg
Moessner Eckhard
Dengle stephan
Gertner Achim

JP2016544443A

November 06, 2019

December 29, 2014

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F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT

C07K19/00; A61K38/00; A61K39/395; A61P35/00; C07K14/47; C07K16/18; C07K16/46

US20100143934
WO2004065569A1
WO2014006124A1

Biochemistry,2006年,Vol.45,p.8350-8357
ZAHND CHRISTIAN,DIRECTED IN VITRO EVOLUTION AND CRYSTALLOGRAPHIC ANALYSIS OF A PEPTIDE-BINDING 以下備考,JOURNAL OF BIOLOGICAL CHEMISTRY,米国,ASBMB,2004年 4月30日,VOL:279, NR:18,,PAGE(S):18870 - 18877,SINGLE CHAIN ANTIBODY FRAGMENT (SCFV) WITH LOW PICOMOLAR AFFINITY,URL,http://dx.doi.org/10.1074/jbc.M309169200

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto

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