Title:
ドルテグラビルナトリウムの新規な水和物
Document Type and Number:
Japanese Patent JP6603306
Kind Code:
B2
Abstract:
The invention relates to novel hydrates of dolutegravir sodium and to processes for their preparation. Furthermore, the invention relates to a novel crystalline form of dolutegravir sodium, which is a useful intermediate for the preparation of one of the novel hydrates. In addition, the invention relates to the use of the novel hydrates for the production of pharmaceutical compositions. Finally, the invention relates to pharmaceutical compositions comprising an effective amount of the novel hydrates, to oral dosage forms comprising said pharmaceutical compositions, to a process for preparing said oral dosage forms, and to the use of said pharmaceutical compositions or dosage forms in the treatment of retroviral infections such as HIV-1 infections.
Inventors:
Hotter, Andreas
Andrea, Thaler
Lever, andria
Jankovic, Villana
Nabelsnik, Clement
Crancal, Uros
Abramovic, Zlinka
Andrea, Thaler
Lever, andria
Jankovic, Villana
Nabelsnik, Clement
Crancal, Uros
Abramovic, Zlinka
Application Number:
JP2017504801A
Publication Date:
November 06, 2019
Filing Date:
July 29, 2015
Export Citation:
Assignee:
Let's Farmer's Medicals Day Day
SANDOZ AKTIENGESELLSCHAFT
SANDOZ AKTIENGESELLSCHAFT
International Classes:
C07D498/14; A61K31/5365; A61K47/14; A61K47/26; A61K47/32; A61K47/36; A61K47/38; A61P31/18
Domestic Patent References:
| JP2012511573A |
Other References:
有機化合物結晶作製ハンドブック-原理とノウハウ-,2008年 7月25日,pp.57-79
Attorney, Agent or Firm:
Kawaguchi International Patent Office