Title:
癌の治療に使用されるＲＮＡトランススプライシング分子（ＲＴＭ）
Document Type and Number:
Japanese Patent JP6608284
Kind Code:
B2
Abstract:
The present invention pertains to a novel pre-mRNA trans-splicing molecule (RTM) comprising a binding region which is complementary to a pre mRNA of a tumor associated gene, and a coding domain which encodes for a suicide gene. Specific embodiments of the present invention relate to RTMs which mediate trans-splicing of a suicide gene, such as thymidine kinase from herpes simplex virus (HSV-tk), with the pre mRNA of the squamous cell carcinoma associated gene solute carrier organic anion transporter family member 1B3 (SLCO1B3). The invention provides RTMs which selectively kill cells expressing SLCO1B3 and which are thus useful in the treatment of cancer, specifically squamous cell carcinoma associated with epidermolysis bullosa. Also provided are methods, kits and pharmaceutical compositions relating to the RTMs in accordance to the invention.
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Inventors:
Johann Bower
Glister, Christina
Koller, Ulrich
Glister, Christina
Koller, Ulrich
Application Number:
JP2015540131A
Publication Date:
November 20, 2019
Filing Date:
October 31, 2013
Export Citation:
Assignee:
Johann Bower
International Classes:
C12N15/00; A61K31/522; A61K31/7088; A61K31/7105; A61K31/711; A61K35/36; A61K35/76; A61K48/00; A61P17/00; A61P17/06; A61P35/00; A61P37/02; A61P43/00; C12N5/10; C12N15/113
Domestic Patent References:
| JP2011529333A |
Other References:
Mol. Cancer Ther., 2011年, Vol.10, pp.233-241
J. Invest. Dermatol., 2009年, Vol.129, Supplement 2, p.S55; 325
Cancer Res., 2008年, Vol.68, pp.10315-10323
Cancer Sci., 2007年, Vol.98, pp.1570-1576
Biochem. Biophys. Res. Commun., 2012年, Vol.418, pp.818-823
J. Invest. Dermatol., 2009年, Vol.129, Supplement 2, p.S55; 325
Cancer Res., 2008年, Vol.68, pp.10315-10323
Cancer Sci., 2007年, Vol.98, pp.1570-1576
Biochem. Biophys. Res. Commun., 2012年, Vol.418, pp.818-823
Attorney, Agent or Firm:
Takashi Shoji