Title:
ＡＬＡＳ１遺伝子の発現を阻害する組成物および方法
Document Type and Number:
Japanese Patent JP6613227
Kind Code:
B2
Abstract:
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting expression of ALAS1, wherein said dsRNA comprises a sense strand and an antisense strand, the antisense strand comprising a region of complementarity to an ALAS1 RNA transcript, which antisense strand comprises at least 22 contiguous nucleotides from the antisense sequence of UAAGAUGAGACACUCUUUCUGGU (SEQ ID NO: 4153) or UAAGAUGAGACACUCTUUCUGGU (SEQ ID NO: 4154).
Inventors:
Brian bettencourt
Kevin Fitzgerald
William Courbes
Robert Jay Desnick
Makiko Yasuda
Kevin Fitzgerald
William Courbes
Robert Jay Desnick
Makiko Yasuda
Application Number:
JP2016519974A
Publication Date:
November 27, 2019
Filing Date:
October 03, 2014
Export Citation:
Assignee:
ALNYLAM PHARMACEUTICALS, INC.
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
International Classes:
C12N15/113; A61K31/7115; A61K31/713; A61P1/16; A61P7/00; A61P25/00; A61P25/04; A61P43/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09
Domestic Patent References:
| JP2011505425A |
Other References:
Silence,2011年,Vol.2,pp.3/1-3/20
Science,2007年,Vol.318,pp.1786-1789
PNAS,2009年,Vol.106, No.52,pp.22510-22515
Science,2007年,Vol.318,pp.1786-1789
PNAS,2009年,Vol.106, No.52,pp.22510-22515
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Kenji Tomita
Hiroshi Yamazaki
Kenji Tomita