Title:
Ｍ９７１キメラ抗原受容体
Document Type and Number:
Japanese Patent JP6643394
Kind Code:
B2
Abstract:
The invention provides a chimeric antigen receptor (CAR) comprising an antigen binding domain comprising SEQ ID NOs: 1-6, a transmembrane domain, and an intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.
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Inventors:
Orentas, Limas, Jay.
Pastan, Ira, H.
Dimitrov, Dimiter, S.
McCall, Crystal, Elle.
Pastan, Ira, H.
Dimitrov, Dimiter, S.
McCall, Crystal, Elle.
Application Number:
JP2018088908A
Publication Date:
February 12, 2020
Filing Date:
May 02, 2018
Export Citation:
Assignee:
THE UNITED STATES OF AMERICA
International Classes:
A61K39/395; A61K31/7088; A61K38/16; A61K48/00; A61P35/00; C07K14/725; C07K16/18; C07K19/00; C12N15/62; C12N15/63
Foreign References:
| WO2009124109A1 |
Other References:
David Marc Davies,Adoptive T-cell Immunotherapy of Cancer Using Chimeric Antigen Receptor-Grafted T Cells,Arch.Immunol.Ther.Exp,2010年,Vol.58,p.165-178
Michel Sadelain,The promise and potential pitfalls of chimeric antigen receptors,Current Opinion in Immunology,2009年,Vol.21,p.215-223
Xiaodong Xiao,Identification and characterization of fully human anti-CD22 monoclonal antibodies,mAbs,2009年,Vol.1,p.297-303
Scott E.James,Antigen Sensitivity of CD22-Specific Chimeric TCR Is Modulated by Target Epitope Distance from the C,The Journal of Immunology,2008年,Vol.180,p.7028-7038
Michel Sadelain,The promise and potential pitfalls of chimeric antigen receptors,Current Opinion in Immunology,2009年,Vol.21,p.215-223
Xiaodong Xiao,Identification and characterization of fully human anti-CD22 monoclonal antibodies,mAbs,2009年,Vol.1,p.297-303
Scott E.James,Antigen Sensitivity of CD22-Specific Chimeric TCR Is Modulated by Target Epitope Distance from the C,The Journal of Immunology,2008年,Vol.180,p.7028-7038
Attorney, Agent or Firm:
Takashima Ichi
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Hirofumi Toma
Atsuko Akai
Tomiya Tozaki
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Hirofumi Toma
Atsuko Akai
Tomiya Tozaki