Title:
α−フェトプロテイン由来糖ペプチドの質量分析法を用いる肝臓がんの診断方法
Document Type and Number:
Japanese Patent JP6643476
Kind Code:
B2
Abstract:
The present invention relates to a diagnosis method of liver cancer using mass spectrometry of ±-fetoprotein(AFP) derived glycopeptide. Particularly, according to the AFP glycopeptide analysis method of the invention, fucosylation rate of the glycopeptide having the sequence composed of Val-Asn-Phe-Thr-Glu-Ile-Gln-Lys is analyzed to diagnose liver cancer in the early developmental grade. In particular, fucosylation rate is higher in the liver cancer patients than in other liver disease patients, so that the comparison of the fucosylation rate can be useful to diagnose or distinguish liver cancer from other liver diseases in the early HCC patients.
Inventors:
You, John Shin
Kim, Gwanghae
Kim, Jin Young
Lee, Ju Young
Kim, Gwanghae
Kim, Jin Young
Lee, Ju Young
Application Number:
JP2018524438A
Publication Date:
February 12, 2020
Filing Date:
April 27, 2017
Export Citation:
Assignee:
Korea Basic Science Institute
International Classes:
G01N27/62; G01N33/68
Foreign References:
| WO2011007764A1 |
Other References:
Hyunsoo Kim,Measurement of Glycosylated Alpha-Fetoprotein Improves Diagnostic Power over the Native Form in Hepatocellular Carcinoma,PLOS ONE,2014年10月,Vol.9/Iss.10,PP.1-12
Attorney, Agent or Firm:
Kiyoji Kuzuwa