Title:
チオプリン製剤による副作用の危険性の判定方法
Document Type and Number:
Japanese Patent JP6644478
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a method for judging a risk for onset of alopecia caused by thiopurine by utilizing genetic polymorphisms associated with a risk for onset of alopecia.SOLUTION: The method for judging a risk for onset of alopecia caused by thiopurine in a subject comprises, from a biological sample derived from the subject, detecting: a polymorphism of 60th base from the 5' end of the 3rd exon of NUDT15 gene; or a polymorphism in a disequilibrium state in which its linkage disequilibrium coefficient r2 with the polymorphism of 60th base from the 5' end of the 3rd exon of the NUDT15 gene is 0.8 or more.SELECTED DRAWING: None
Inventors:
Youichi Kakuda
Takeo Naito
Yoshitaka Kiuchi
Toru Shimosegawa
Takeo Naito
Yoshitaka Kiuchi
Toru Shimosegawa
Application Number:
JP2015091401A
Publication Date:
February 12, 2020
Filing Date:
April 28, 2015
Export Citation:
Assignee:
Tohoku University
International Classes:
C12Q1/68; A61K31/52; A61P1/00; A61P29/00; C12Q1/6876
Domestic Patent References:
| JP2014520092A |
Foreign References:
| WO2015111852A1 |
Other References:
Andoh, A. et al.,"Monitoring 6-thioguanine nucleotide concentrations in Japanese patients with inflammatory bowel disease",J. Gastroenterol. Hepatol.,2008年,Vol. 23,pp. 1373-1377
Yang, S. K. et al.,"A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia",Nat. Genet.,2014年,Vol. 46,pp. 1017-1020, Supplementary Information
Yang, S. K. et al.,"A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia",Nat. Genet.,2014年,Vol. 46,pp. 1017-1020, Supplementary Information
Attorney, Agent or Firm:
Patent Business Corporation Saegusa International Patent Office