Title:
ソノポレーション用超音波送信装置
Document Type and Number:
Japanese Patent JP6656635
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To promote introduction of an introducing material into a biological cell while reducing damage given to the biological cell in executing sonoporation.SOLUTION: A transmission sequence of an ultrasound 18 for sonoporation includes a plurality of transmission periods Tand a plurality of stop periods Tin which transmission of the ultrasound 18 is stopped. In each transmission period T, a pulse wave period Tin which the ultrasound 18 is transmitted and a pause period Tin which transmission of the ultrasound 18 is paused are alternately repeated. The ultrasound 18 transmitted in each pulse wave period Thas acoustic pressure necessary for collapsing micro bubbles. For a time length of each pulse wave period T, a time length necessary for collapsing micro bubbles is set. Thus, the ultrasound 18 is intermittently transmitted in each transmission period T, so that a large number of micro bubbles can be collapsed while reducing acoustic energy that a biological cell receives from the ultrasound 18, that is, damage that the biological cell receives from the ultrasound 18.SELECTED DRAWING: Figure 5
Inventors:
Kazuo Maruyama
Ryo Suzuki
Taiki Omata
Go Mochizuki
Ryo Suzuki
Taiki Omata
Go Mochizuki
Application Number:
JP2015093764A
Publication Date:
March 04, 2020
Filing Date:
May 01, 2015
Export Citation:
Assignee:
Educational Corporation Teikyo University
Mu research institute
Mu research institute
International Classes:
C12M1/42; A01G7/00; A01G7/06; A61B8/00
Domestic Patent References:
| JP2008178590A |
Foreign References:
| WO2015047502A1 |
Other References:
Biochemical and Biophysical Research Communications, 2006, Vol.343, pp.470-474
J. Controlled Release, 2010, Vol.145, pp.40-48
日本超音波医学会学術集会プログラム・講演抄録集 Japanese Journal of Medical Ultrasonics Vol.38, Supplement,(社)日本超音波医学会 千田 彰一,第38巻,S309,第S309頁下欄84-基-008
Drug Delivery System, 2014, Vol.29-5, pp.456-458
J. Controlled Release, 2010, Vol.145, pp.40-48
日本超音波医学会学術集会プログラム・講演抄録集 Japanese Journal of Medical Ultrasonics Vol.38, Supplement,(社)日本超音波医学会 千田 彰一,第38巻,S309,第S309頁下欄84-基-008
Drug Delivery System, 2014, Vol.29-5, pp.456-458
Attorney, Agent or Firm:
Patent Corporation yki International Patent Office