Title:
関節リウマチの診断のための自己抗原
Document Type and Number:
Japanese Patent JP6663000
Kind Code:
B2
Abstract:
Disclosed herein are methods of diagnosing Rheumatoid arthritis in a subject comprising determining whether the subject is immunologically reactive with N-acetylglucosamine-6-sulfatase and/or filamin-A, wherein immunological reactivity of the subject to one or more of N-acetylglucosamine-6-sulfatase or filamin-A, as compared to an appropriate control, indicates the subject has rheumatoid arthritis. Examples of specific assays and kits for use with the methods are also disclosed.
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Inventors:
Stia Arency.
Doruan Elise Yi.
Doruan Elise Yi.
Application Number:
JP2018511342A
Publication Date:
March 11, 2020
Filing Date:
May 12, 2016
Export Citation:
Assignee:
The General Hospital Corporation Doing Business As Massachusetts General Hospital
International Classes:
G01N33/53; C12Q1/06
Domestic Patent References:
| JP2000512008A | ||||
| JP2014523532A | ||||
| JP5420134A |
Foreign References:
| US20150010631 | ||||
| US20130302329 | ||||
| US20050130117 | ||||
| WO2004078098A2 | ||||
| US20110052488 |
Other References:
Pianta A.,IDENTIFICATION OF N-ACETYLGLUCOSAMINE-6-SULFATASE AND FILAMIN A AS NOVEL TARGETS OF AUTOIMMUNE T AND B CELL RESPONSES IN RHEUMATOID ARTHRITIS,Annals of the Rheumatic Diseases,2015年 6月,Vol.74 No.Suppl.2,Page.112 OP0116
Annalisa Pianta,Two rheumatoid arthritis-specific autoantigens correlate microbial immunity with autoimmune responses in joints,The Journal of Clinical Investigation,2017年 8月,Vol.127 No.8,Page.2946-2956
Van Steendam Katleen,Quantification of IFNγ- and IL17-producing cells after stimulation with citrullinated proteins in healthy subjects and RA patients,Rheumatol Int,2013年,Vol.33 No.10,Page.2661-2664
Annalisa Pianta,Two rheumatoid arthritis-specific autoantigens correlate microbial immunity with autoimmune responses in joints,The Journal of Clinical Investigation,2017年 8月,Vol.127 No.8,Page.2946-2956
Van Steendam Katleen,Quantification of IFNγ- and IL17-producing cells after stimulation with citrullinated proteins in healthy subjects and RA patients,Rheumatol Int,2013年,Vol.33 No.10,Page.2661-2664
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto