Title:
３−置換カルボニル−ナフト［２，３−ｂ］フラン誘導体又はその薬学的に許容される塩
Document Type and Number:
Japanese Patent JP6695275
Kind Code:
B2
Abstract:
wherein X is an oxygen atom and the like; Y is —CO—, —SO2— and the like; R1 is an optionally-substituted C1-6 alkyl group, an optionally-substituted C1-6 alkylcarbonyl group and the like; R2 is an optionally-substituted C1-6 alkyl group, an optionally-substituted C1-6 alkoxy group, an optionally-substituted amino group, an optionally-substituted 5- to 12-membered monocyclic or polycyclic saturated heterocyclic group and the like; R3, R4, R5, and R6 are independently a hydrogen atom and the like which exhibits excellent effects in suppressing the proliferation and sphere-forming ability of cancer cells, and can be useful as an antitumor drug or cell growth inhibitor.
Inventors:
Toshihiko Sone
Hirose Wataru
Naoaki Shimada
Lee, Chang, Jee.
Lee, Way
David, David
Hirose Wataru
Naoaki Shimada
Lee, Chang, Jee.
Lee, Way
David, David
Application Number:
JP2016548371A
Publication Date:
May 20, 2020
Filing Date:
February 06, 2015
Export Citation:
Assignee:
Boston Biomedical, Inc.
International Classes:
C07D307/92; A61K31/343; A61K31/443; A61K31/496; A61K31/5377; A61P35/00; A61P35/02; C07D405/04
Domestic Patent References:
| JP2010539095A | ||||
| JP2002517397A |
Other References:
LEE, H.-J. et al.,Bioorganic & Medicinal Chemistry,2003年,Vol. 11,pp. 1511-1519
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WU, Y.-L. et al.,Tetrahedron,2001年,Vol. 57,pp. 5543-5549
HU, H.-Y. et al.,Synthesis,2005年,No. 10,pp. 1605-1610
TSENG, C.-M. et al.,Tetrahedron,2004年,Vol. 60,pp. 12249-12260
CHUANG, C.-P. et al.,Tetrahedron,1998年,Vol. 54,pp. 10043-10052
CHUANG, C.-P. et al.,Tetrahedron,1999年,Vol. 55,pp. 11229-11236
YI, H.-W. et al.,Journal of Heterocyclic Chemistry,2005年,Vol. 42,pp. 147-151
SUN, J.-W. et al.,The Journal of Organic Chemistry,2013年,Vol. 78,pp. 10560-10566
WANG, W. et al.,The Journal of Organic Chemistry,2013年,Vol. 78,pp. 6211-6222
SHUKLA, G. et al.,RSC Advances,2013年,Vol. 3,Supporting Information,1.3 Experimental Data
STASEVYCH, M. V. et al.,Chemistry of Heterocyclic Compounds,2008年,Vol. 44, No. 7,pp. 897-898
PARK, H. J. et al.,European Journal of Pharmacology,2005年,Vol. 527,pp. 31-36
CHOI, I. et al.,Journal of the Korean Chemical Society,2005年,Vol. 49, No. 5,pp. 449-460
KUEHNE, M. E. et al.,The Journal of Organic Chemistry,1972年,Vol. 37, No. 25,pp. 4031-4036
GHERA, E. et al.,Tetrahedron Letters,1986年,Vol. 27, No. 33,pp. 3935-3938
PARK, H. J. et al.,Bioscience, Biotechnology, and Biochemistry,2003年,Vol. 67, No. 9,pp. 1944-1949
WU, Y.-L. et al.,Tetrahedron,2001年,Vol. 57,pp. 5543-5549
HU, H.-Y. et al.,Synthesis,2005年,No. 10,pp. 1605-1610
TSENG, C.-M. et al.,Tetrahedron,2004年,Vol. 60,pp. 12249-12260
CHUANG, C.-P. et al.,Tetrahedron,1998年,Vol. 54,pp. 10043-10052
CHUANG, C.-P. et al.,Tetrahedron,1999年,Vol. 55,pp. 11229-11236
YI, H.-W. et al.,Journal of Heterocyclic Chemistry,2005年,Vol. 42,pp. 147-151
SUN, J.-W. et al.,The Journal of Organic Chemistry,2013年,Vol. 78,pp. 10560-10566
WANG, W. et al.,The Journal of Organic Chemistry,2013年,Vol. 78,pp. 6211-6222
SHUKLA, G. et al.,RSC Advances,2013年,Vol. 3,Supporting Information,1.3 Experimental Data
STASEVYCH, M. V. et al.,Chemistry of Heterocyclic Compounds,2008年,Vol. 44, No. 7,pp. 897-898
PARK, H. J. et al.,European Journal of Pharmacology,2005年,Vol. 527,pp. 31-36
CHOI, I. et al.,Journal of the Korean Chemical Society,2005年,Vol. 49, No. 5,pp. 449-460
KUEHNE, M. E. et al.,The Journal of Organic Chemistry,1972年,Vol. 37, No. 25,pp. 4031-4036
GHERA, E. et al.,Tetrahedron Letters,1986年,Vol. 27, No. 33,pp. 3935-3938
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takeshi Komatani
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takeshi Komatani
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto