Title:
リュープロレリンの製造方法
Document Type and Number:
Japanese Patent JP6703669
Kind Code:
B2
Abstract:
The purpose of the present invention is to provide a method for producing leuprorelin that allows a crude product of high purity to be obtained in a shorter production period, as compared with conventional production methods. Provided is a method for producing leuprorelin, comprising the following steps a through d: step a for obtaining an N-Fmoc-protected peptide by condensing a protected amino acid or peptide and an N-Fmoc protected amino acid in an organic solvent or an organic solvent mixture; step b for adding a water-soluble amine to the reaction solution following the condensation reaction; step c for deprotecting the Fmoc group from the protected amino group in the presence of the water-soluble amine; and step d for obtaining an organic layer by adding acid to neutralize the reaction solution, additionally adding an acidic aqueous solution to wash the product, carrying out liquid separation, and then removing the aqueous layer.
More Like This:
Inventors:
Ichiro Shima
Natsumi Iwanaga
Kosuke Suzuki
Fujita Shuji
Natsumi Iwanaga
Kosuke Suzuki
Fujita Shuji
Application Number:
JP2019548093A
Publication Date:
June 03, 2020
Filing Date:
April 13, 2019
Export Citation:
Assignee:
jitsubo corporation
International Classes:
C07K7/06; C07K1/06; C07K1/10; C07K14/59
Foreign References:
| WO2016140232A1 | ||||
| US20130060004 |
Other References:
Organic Process Research and Development,2003年,vol.7,p.28-37
Attorney, Agent or Firm:
Kenichi Osawa