Title:
ＥＺＨ２の阻害剤
Document Type and Number:
Japanese Patent JP6704040
Kind Code:
B2
Abstract:
The present invention relates to compounds that inhibit activity of the histone lysine methyltransferase, Enhancer of Zeste Homolog 2 (EZH2), pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, such as hematologic and solid tumors.
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Inventors:
Dominguez, Esteban
Guo, Deki
Madder, Marie Margaret
Nguyen, Anne-Kuan Hanner
Del Prado, Miriam Philadelphia
Richett, Michael Enrico
Rodriguez, Michael John
Yp, Yvonne Emai
Yu, Quo-Long
Guo, Deki
Madder, Marie Margaret
Nguyen, Anne-Kuan Hanner
Del Prado, Miriam Philadelphia
Richett, Michael Enrico
Rodriguez, Michael John
Yp, Yvonne Emai
Yu, Quo-Long
Application Number:
JP2018510778A
Publication Date:
June 03, 2020
Filing Date:
August 22, 2016
Export Citation:
Assignee:
Eli Lilly and Company
International Classes:
C07D495/04; A61K31/4412; A61K31/55; A61K33/243; A61P1/00; A61P11/00; A61P15/00; A61P19/00; A61P35/00; A61P43/00
Domestic Patent References:
| JP2004504342A | ||||
| JP2004524277A | ||||
| JP2005508322A | ||||
| JP2015511603A | ||||
| JP2015518053A |
Foreign References:
| WO2014177982A1 | ||||
| WO2014097041A1 |
Attorney, Agent or Firm:
Hiroshi Kobayashi
Eiji Katayama
Norio Omori
Saori Oga
Yasuhito Suzuki
Eiji Katayama
Norio Omori
Saori Oga
Yasuhito Suzuki