Title:
ＥｒｂＢ３活性化に伴うシグナルの伝達抑制物質及びそのスクリーニング方法
Document Type and Number:
Japanese Patent JP6729926
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a screening method of a transmission inhibition material of the signal accompanied with the cell membrane receptor ErbB3 activation and a screening method of the signal transmission inhibition material.SOLUTION: A screening method of a transmission inhibition material of a signal accompanied with ErbB3 activation is characterized in that the material coupled with a domain III of the ErbB3 is selected. The formation of ErbB2-ErbB3 hetero dimer is inhibited by the material capable of interacting with the region of the domain III of the ErbB3, and an excessive signal accompanied with the activation of the ErbB3 can be suppressed. The peptide derived from a Necl-4 of domain Ig3 can interact with the domain III region of the ErbB3. According to the screening method of the transmission inhibition material of the signal accompanied with the ErbB3 activation of the present invention, not only the antibody, but also the transmission inhibition material of the signal accompanied with the ErbB3 activation that can be simply manufactured at a low cost can be selected.SELECTED DRAWING: Figure 1
Inventors:
Yoshimi Takai
Kiyoto Mizutani
Keida Castle Xun
Kiyoto Mizutani
Keida Castle Xun
Application Number:
JP2016096427A
Publication Date:
July 29, 2020
Filing Date:
May 12, 2016
Export Citation:
Assignee:
National University Corporation Kobe University
International Classes:
G01N33/50; C12Q1/02; G01N33/15
Domestic Patent References:
| JP2014530215A | ||||
| JP2015500830A |
Foreign References:
| WO2016059602A2 |
Other References:
Hirokazu SUGIYAMA et al.,Interaction of Necl-4/CADM4 with ErbB3 and Integrin alpha6beta4 and Inhibition of ErbB2/ErbB3 Signaling and Hemidesmosome Disassembly,Genes to Cells,2013年,Vol.18,519-528
Attorney, Agent or Firm:
Takashi Shoji
Yuriko Shinobu
Takuya Osugi
Aki Soga
Yuriko Shinobu
Takuya Osugi
Aki Soga