Title:
ブロモドメイン阻害剤
Document Type and Number:
Japanese Patent JP6734896
Kind Code:
B2
Abstract:
The present invention relates to substituted heterocyclic derivative compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of cancer and neoplastic disease.
Inventors:
Bennett, Michael, John
Betancourt, Juan, Manuel
Boroar, Amov
Kardeau, Stefin, W.
Stafford, Jeffrey, Alan
Vir, james, marvin
Betancourt, Juan, Manuel
Boroar, Amov
Kardeau, Stefin, W.
Stafford, Jeffrey, Alan
Vir, james, marvin
Application Number:
JP2018169146A
Publication Date:
August 05, 2020
Filing Date:
September 10, 2018
Export Citation:
Assignee:
Celgene Quantisell Research, Inc.
International Classes:
A61K31/4355; C07D213/04; A61K31/4365; A61K31/437; A61K31/4375; A61K31/4412; A61K31/4427; A61K31/443; A61K31/4439; A61K31/472; A61K31/4725; A61K31/4965; A61K31/4985; A61K31/50; A61K31/506; A61K31/519; A61K31/5383; A61P35/00; A61P43/00; C07D213/69; C07D213/70; C07D213/74; C07D217/24; C07D237/14; C07D241/20; C07D401/04; C07D401/14; C07D405/04; C07D405/06; C07D405/12; C07D409/04; C07D413/04; C07D413/06; C07D417/14; C07D471/04; C07D487/04; C07D491/048; C07D495/04; C07D498/04
Domestic Patent References:
| JP2015523354A | ||||
| JP2016517417A | ||||
| JP2008513414A | ||||
| JP2013500306A | ||||
| JP2008533032A | ||||
| JP2012513437A | ||||
| JP2010504287A | ||||
| JP2010540452A | ||||
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| JP2010526831A |
Attorney, Agent or Firm:
Akio Miyazaki
Masaaki Ogata
Masaaki Ogata