Title:
がんの処置における使用のためのＰＣＡＦおよびＧＣＮ５阻害剤としての式（Ｉ）のフタラジン誘導体
Document Type and Number:
Japanese Patent JP6767969
Kind Code:
B2
Abstract:
wherein ring A, R1, R3, R4, R5, and each Re have any of the values defined in the specification. Also included are novel compounds of Formula (I) and salts thereof, as well as pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof.
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Inventors:
Albrecht, Brian Kay.
Coat, alexander
Crawford, Terry
Duplessis, Martin
Good, Andrew Charles
Leblanc, eve
Magnuson, stephen
Nasveschak, Christopher Gee.
Pastor, richard
Romero, F. Antony
Taylor, Alexander M.
Coat, alexander
Crawford, Terry
Duplessis, Martin
Good, Andrew Charles
Leblanc, eve
Magnuson, stephen
Nasveschak, Christopher Gee.
Pastor, richard
Romero, F. Antony
Taylor, Alexander M.
Application Number:
JP2017512683A
Publication Date:
October 14, 2020
Filing Date:
September 03, 2015
Export Citation:
Assignee:
Genentech, Incorporated
International Classes:
C07D237/26; A61K31/282; A61K31/337; A61K31/437; A61K31/501; A61K31/502; A61K31/5025; A61K31/517; A61K31/5377; A61K31/55; A61K33/24; A61K45/00; A61P1/04; A61P1/16; A61P1/18; A61P3/04; A61P3/10; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P17/08; A61P19/00; A61P19/02; A61P19/06; A61P19/08; A61P19/10; A61P21/00; A61P29/00; A61P31/18; A61P33/00; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D237/30; C07D237/34; C07D401/12; C07D403/12; C07D405/12; C07D471/04; C07D487/04
Domestic Patent References:
| JP2008504348A | ||||
| JP49031683A | ||||
| JP2016510786A | ||||
| JP2007532580A | ||||
| JP2005501848A |
Foreign References:
| KR1020130042847A | ||||
| WO2014068388A1 | ||||
| GB808636B |
Other References:
WIESLAW MALINKA; ALEKSANDRA REDZICKA; OLIVIER LOZACH,NEW DERIVATIVES OF PYRROLO[3,4-D]PYRIDAZINONE AND THEIR ANTICANCER EFFECTS,IL FARMACO,2004年 6月 1日,VOL:59, NR:6,PAGE(S):457 - 462,URL,http://dx.doi.org/10.1016/j.farmac.2004.03.002
FARMACO,1998年,53(7),475-479
野崎正勝 等,創薬化学,株式会社化学同人,1995年,第1版,p.98-99
C.G.WERMUTH編,『最新 創薬化学 上巻』,株式会社テクノミック,1998年 8月15日,235-271頁,13章 等価置換に基づく分子の変換
Bioorganic & Medicinal Chemistry Letters,2013年,23(7),2007-2013
BRIAN G PRING; SWAHN; CARL-GUNNAR,SYNTHESIS AND MECHANISM OF FORMATION OF 2,3-DIALKYL-1,2,3,4-TETRAHYDROPHTHALAZINE-1, 以下備考,ACTA CHEMICA SCANDINAVICA,1973年 1月25日,PAGE(S):1891-1899,4-DIONES BY UTILIZING AN O-N REARRANGEMENT OF 1-ALKOXY-3-ALKYL-3,4-DIHYDROPHTHALAZIN-4-ONES,URL,http://dx.doi.org/10.3891/acta.chem.scand.27-1891
Acta Poloniae Pharmaceutica,1965年,22(2),111-15
Acta Chimica Hungarica,1983年,112(1),65-82
Journal of Heterocyclic Chemistry,1967年,4(4),491-9
Canadian Journal of Chemistry,1966年,44(17),2095-100
FARMACO,1998年,53(7),475-479
野崎正勝 等,創薬化学,株式会社化学同人,1995年,第1版,p.98-99
C.G.WERMUTH編,『最新 創薬化学 上巻』,株式会社テクノミック,1998年 8月15日,235-271頁,13章 等価置換に基づく分子の変換
Bioorganic & Medicinal Chemistry Letters,2013年,23(7),2007-2013
BRIAN G PRING; SWAHN; CARL-GUNNAR,SYNTHESIS AND MECHANISM OF FORMATION OF 2,3-DIALKYL-1,2,3,4-TETRAHYDROPHTHALAZINE-1, 以下備考,ACTA CHEMICA SCANDINAVICA,1973年 1月25日,PAGE(S):1891-1899,4-DIONES BY UTILIZING AN O-N REARRANGEMENT OF 1-ALKOXY-3-ALKYL-3,4-DIHYDROPHTHALAZIN-4-ONES,URL,http://dx.doi.org/10.3891/acta.chem.scand.27-1891
Acta Poloniae Pharmaceutica,1965年,22(2),111-15
Acta Chimica Hungarica,1983年,112(1),65-82
Journal of Heterocyclic Chemistry,1967年,4(4),491-9
Canadian Journal of Chemistry,1966年,44(17),2095-100
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita