Title:
イミド系タンパク質分解モジュレーター及び関連する使用方法
Document Type and Number:
Japanese Patent JP6778114
Kind Code:
B2
Abstract:
The description relates to imide-based compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the description provides compounds, which contain on one end a ligand which binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type.
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Inventors:
Cluse Craig
Clew Andrew P.
Don Hankin
One Jin
Chiang Emin
Jin Maechon
Clew Andrew P.
Don Hankin
One Jin
Chiang Emin
Jin Maechon
Application Number:
JP2016563103A
Publication Date:
October 28, 2020
Filing Date:
April 14, 2015
Export Citation:
Assignee:
ARVINAS OPERATIONS, INC.
International Classes:
C07D401/04; A61K31/454; A61K31/506; A61K31/551; A61K45/00; A61P1/04; A61P3/00; A61P3/04; A61P3/10; A61P7/04; A61P9/00; A61P9/12; A61P11/06; A61P13/12; A61P15/08; A61P25/28; A61P31/12; A61P31/18; A61P35/00; A61P35/02; A61P43/00; C07D401/14; C07D417/14; C07D495/14
Domestic Patent References:
| JP2008534631A | ||||
| JP2004525889A | ||||
| JP2010502627A | ||||
| JP2012532929A |
Foreign References:
| WO2013106643A1 |
Other References:
Organic & Biomolecular Chemistry,2013年,11(29),p.4757-4763
Bioorganic & Medicinal Chemistry Letters,2013年,23(1),p.360-365
Bioorganic & Medicinal Chemistry Letters,2009年,19(3),p.878-881
Bioorganic & Medicinal Chemistry Letters,2013年,23(1),p.360-365
Bioorganic & Medicinal Chemistry Letters,2009年,19(3),p.878-881
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto