Title:
モジュレータアッセイ
Document Type and Number:
Japanese Patent JP6781718
Kind Code:
B2
Abstract:
It has been demonstrated that certain compounds bind to TNT and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.
Inventors:
O'Connell, James Philip
John Robert, Porter
Lawson, Alestea
Croplin, Boris
Lapecchi, Stephen Edward
Norman, Timothy John
Valero, Graham John
John Robert, Porter
Lawson, Alestea
Croplin, Boris
Lapecchi, Stephen Edward
Norman, Timothy John
Valero, Graham John
Application Number:
JP2017565155A
Publication Date:
November 04, 2020
Filing Date:
October 22, 2015
Export Citation:
Assignee:
UCB Biopharma SRL
International Classes:
G01N33/50; A61K31/4439; A61K38/16; A61K45/00; A61K47/55; A61P1/04; A61P9/00; A61P17/06; A61P19/02; A61P25/00; A61P25/04; A61P25/08; A61P25/16; A61P25/28; A61P29/00; A61P37/02; G01N21/64; G01N27/62; G01N33/15
Domestic Patent References:
| JP2012509312A |
Foreign References:
| US20140165223 |
Other References:
Mechanism of Suramin-Induced Deoligomerization of Tumor Necrosis Factor alpha,Biochemistry,1995年,34,6344-6350
A Novel Small-Molecule Tumor Necrosis Factor alpha Inhibitor Attenuates Inflammation in a Hepatitis Mouse Model,The Journal of Biological Chemistry,2014年 5月,Vol.289, No.18,12457-12466
Small-Molecule Inhibition of TNF-alpha,Science,2005年11月,Vol.310,1022-1025
Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism,ACS Chemical Biology,2011年,Vol.6, No.6,636-647
New Binding Mode to TNF-Alpha Revealed by Ubiquitin-Based Artificial Binding Protein,Plos One,2012年 2月,Vol.7, No.2,e31298
A Novel Small-Molecule Tumor Necrosis Factor alpha Inhibitor Attenuates Inflammation in a Hepatitis Mouse Model,The Journal of Biological Chemistry,2014年 5月,Vol.289, No.18,12457-12466
Small-Molecule Inhibition of TNF-alpha,Science,2005年11月,Vol.310,1022-1025
Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism,ACS Chemical Biology,2011年,Vol.6, No.6,636-647
New Binding Mode to TNF-Alpha Revealed by Ubiquitin-Based Artificial Binding Protein,Plos One,2012年 2月,Vol.7, No.2,e31298
Attorney, Agent or Firm:
Asamura patent office