抗がん薬治療に関連する副作用である疲労、悪液質、疼痛、認知低下及び造血幹細胞減少を予防する又は寛解させるための、ナフトキノン系化合物を有効成分として含む組成物

Japanese Patent JP6785367

B2

The present invention relates to a composition comprising a naphthoquinone-based compound as an active ingredient, for preventing or ameliorating fatigue, cachexia, pain, cognitive decline, and hematopoietic stem cell reduction which are side effects related to anticancer drug treatment. Specifically, it has been confirmed that the naphthoquinone-based compounds, dunnione and ²-lapachone, reduce the secretion and production of inflammatory cytokines which are increased by the anticancer drug treatment, and prevent fatigue, cachexia, cognitive decline, and hematopoietic stem cell reduction which are side effects associated with anticancer drug treatment, and thus the dunnione and ²-lapachone compounds, pharmaceutically acceptable salts, prodrugs, solvates or isomers thereof can be effectively used as a pharmaceutical composition for preventing or ameliorating any one or more side effects related to anticancer drug treatment selected from the group consisting of fatigue, cachexia, pain, cognitive decline, and hematopoietic stem cell reduction.

Seo, Hongsob
Kim, Hyun-Jin
Oh, Gee-so
Lee, Song Hoon
Kadoka, Dependra

JP2019509451A

November 18, 2020

April 28, 2017

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NADIANBIO Ltd.

A61K31/343; A61K31/352; A61P25/28; A61P29/00

KR1020140058734A

Biomol. Ther.,2015年,Vol.23, No.5,p.449-457
Biochemical and Biophysical Research Communications,2015年,Vol.467,p.697-703
J. Gastroenterol,2013年,Vol.48,p.574-594
Annals of Oncology,2015年,Vol.26,p.1446-1451
Med. Res. Rev.,1999年,Vol.19, No.3,p.223-248

Norihito Yamao
Yasushi Ochiai

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