Title:
免疫原性化合物
Document Type and Number:
Japanese Patent JP6792452
Kind Code:
B2
Abstract:
The present application relates to an immunostimulatory compound comprising an immunostimulant portion and a peptide portion. The peptide portion is not a disease-associated immunogen. Furthermore, the peptide portion has an amino acid sequence in which 75% or less of the amino acid residues are hydrophobic and/or has an isoelectric point of 5 or greater. The compounds of the invention address the problem of systemic distribution of immunostimulants causing unwanted side effects. The inventors have found that the physicochemical properties of the immunostimulant can be controlled by covalent linkage to a peptide. Further physicochemical properties may be modified in a useful manner by incorporating additional features.
Inventors:
Georges, Bertrand
Application Number:
JP2016555933A
Publication Date:
November 25, 2020
Filing Date:
December 02, 2014
Export Citation:
Assignee:
Ultimune UK Limited
International Classes:
A61K39/39; A61K39/00; A61K39/35; A61K47/64; A61P31/00; A61P35/00; A61P37/04; A61P37/06
Domestic Patent References:
| JP2008539252A |
Foreign References:
| WO2012090002A1 |
Other References:
Shukla NM, et al.,Toward self-adjuvanting subunit vaccines: model peptide and protein antigens incorporating covalently bound toll-like receptor-7 agonistic imidazoquinolines,Bioorganic & medicinal chemistry letters,2011年,Vol.21, No.11,p.3232-3236
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Naoko Kikuta
Wakako Nomura
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Naoko Kikuta
Wakako Nomura