Title:
分解可能連結子を含む光増感剤−ペプチド結合体及びそれを含む光力学診断または治療用組成物
Document Type and Number:
Japanese Patent JP6797276
Kind Code:
B2
Abstract:
The present invention relates to a conjugate for photodynamic diagnosis or treatment in which a peptide binds with a photosensitizer via an intracellularly degradable linkage, and to a composition for photodynamic diagnosis or treatment including the same. The conjugate of the present invention generates no fluorescent signal and reactive oxygen in normal tissues or during the circulation in the blood by quenching a fluorescent signal and reactive oxygen generation ability of the photosensitizer. After the conjugate is selectively absorbed into target cells, a linker is degraded in the cells to increase the distance between tryptophan included in the peptide and the photosensitizer, and the quenching action is terminated to generate a strong fluorescence signal and induce active generation of reactive oxygen. Therefore, the conjugate according to the present invention has high tissue permeability, shows a high photodynamic therapeutic effect in only target cells while being safe in normal cells, and can obtain a good diagnostic image having a high ratio of target signal to background.
Inventors:
Choi Yeon-Daw
Kim Ji-su
Kim Ji-su
Application Number:
JP2019501915A
Publication Date:
December 09, 2020
Filing Date:
July 04, 2017
Export Citation:
Assignee:
National Cancer Center
International Classes:
C07K19/00; A61K31/409; A61K38/17; A61K47/22; A61K47/42; A61K47/50; A61K49/14; A61P35/00; A61P43/00; C07K5/068; C07K5/09; C07K7/08
Foreign References:
| WO2016063959A1 |
Other References:
J Porphyr Phthalocyanines,2016年 1月,vol.20、no.1-4,p.352-366
Journal of Materials Chemistry B,2012年,DOI:10.1039/c2tb00287f
Journal of Materials Chemistry B,2012年,DOI:10.1039/c2tb00287f
Attorney, Agent or Firm:
Junya Tanaka
Mizuya Kamiya
Kyoko Sakoda
Mizuya Kamiya
Kyoko Sakoda