Title:
新規な連結体及び生体分子と薬物との特異的共役におけるその使用
Document Type and Number:
Japanese Patent JP6817288
Kind Code:
B2
Abstract:
Disclosed are linkers containing a 2,3-disubstituted succinic group, or 2-monosubstituted, or 2,3-disubstituted fumaric or maleic group for conjugation of two or more compounds/cytotoxic agents per linker to a cell-binding molecule through bridge linking pairs of thiols on the cell-binding molecule, as well as methods of making such linkers, of using such linkers in making homogeneous conjugates, and of application of the conjugates in treatment of cancers, infections and autoimmune disorders.
Inventors:
ZHAO,Robert Yongxin
Application Number:
JP2018506984A
Publication Date:
January 20, 2021
Filing Date:
August 10, 2015
Export Citation:
Assignee:
HANGZHOU DAC BIOTECH CO.,LTD.
International Classes:
C07D207/404; A61K31/454; A61K45/00; A61K47/54; A61K47/56; A61K47/66; A61K47/68; A61P31/04; A61P35/00; A61P37/02; A61P43/00; C07D417/14; C07D519/00; C07K14/475; C07K14/52; C07K14/575; C07K14/705; C07K16/18; C07K16/28; C07K16/30; C07K16/46
Domestic Patent References:
| JP2015510877A | ||||
| JP2015500287A | ||||
| JP50082015A |
Foreign References:
| WO2014197854A1 | ||||
| WO2014009774A1 |
Other References:
Van Wuytswinkel, Grete; Verheyde, Bert; Compernolle, Frans; Dehaen, Wim, et al,A convergent synthesis of heterocyclic dendrimers using the 1,3-dipolar,J. Chem. Soc., Perkin Trans. 1,英国,Royal Society of Chemistry,2000年,(9),1337-1340
Hashmi, A. Stephen K.; Grundl, Marc A.; Nass, Bolte, Michael、et al,Photochemical synthesis of prochiral dialkyl 3,3-dialkylcyclopropene-1,2-dicarboxylates with facial shielding substituents and related substrates,European Journal of Organic Chemistry,ドイツ,Wiley-VCH,2001年,24,4705-4732
Smet, Mario; Metten, Kris; Dehaen, Wim,Synthesis of new AB2 monomers for polymerization to hyperbranched polymers by 1,3-dipolar cycloaddition,Collection of Czechoslovak Chemical Communications,2004年,69(5),1097-1108
Hashmi, A. Stephen K.; Grundl, Marc A.; Nass, Bolte, Michael、et al,Photochemical synthesis of prochiral dialkyl 3,3-dialkylcyclopropene-1,2-dicarboxylates with facial shielding substituents and related substrates,European Journal of Organic Chemistry,ドイツ,Wiley-VCH,2001年,24,4705-4732
Smet, Mario; Metten, Kris; Dehaen, Wim,Synthesis of new AB2 monomers for polymerization to hyperbranched polymers by 1,3-dipolar cycloaddition,Collection of Czechoslovak Chemical Communications,2004年,69(5),1097-1108
Attorney, Agent or Firm:
Hiroe Associates Patent Office