Title:
トレプロスチニルの製造方法
Document Type and Number:
Japanese Patent JP6820255
Kind Code:
B2
Abstract:
Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anhydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. Also disclosed are treprostinil intermediates and the preparation of the intermediates.
Inventors:
Imre Juhas
Iren Holtberg
Tamas Altshire
Istburn Rashzolofi
Agnes Nazine Volco
Imre Rojam Barshky
Garbol Havashy
Giuganna Cardos
Peter Bouza-Rantos
Iren Holtberg
Tamas Altshire
Istburn Rashzolofi
Agnes Nazine Volco
Imre Rojam Barshky
Garbol Havashy
Giuganna Cardos
Peter Bouza-Rantos
Application Number:
JP2017518846A
Publication Date:
January 27, 2021
Filing Date:
September 28, 2015
Export Citation:
Assignee:
Kinoin Jiojicel Aceille Bezier Sete Thermekek Jyara See El Te
International Classes:
C07C27/02; C07C43/23; C07C49/755; C07C49/84; C07C59/72; C07C69/76; C07D309/12; C07F7/18
Domestic Patent References:
| JP2007501281A | ||||
| JP2017522304A | ||||
| JP2013528621A | ||||
| JP2013047224A |
Foreign References:
| WO2014089385A1 | ||||
| US20140256730 | ||||
| WO2012088607A1 | ||||
| US20140275616 | ||||
| WO2014150203A1 | ||||
| WO2012009816A1 | ||||
| WO2013174848A1 |
Attorney, Agent or Firm:
Junji Yuda
Noriyuki Takebayashi
Noriyuki Takebayashi