Title:
無細胞ヌクレオソームの濃縮のための方法
Document Type and Number:
Japanese Patent JP6831841
Kind Code:
B2
Abstract:
The present invention relates to the use of a histone H1 binding agent for detecting, isolating and/or purifying cell free nucleosomes of tumor origin from a biological sample. The invention also describes methods of negative or positive selection using histone H1 binding agents, in order to enrich a sample for cell free nucleosomes of tumor origin.
Inventors:
Jacob Vincent Mikarev
Mark Edward Eccleston
Mark Edward Eccleston
Application Number:
JP2018520599A
Publication Date:
February 17, 2021
Filing Date:
October 21, 2016
Export Citation:
Assignee:
Belgian Bolchon SPRL
International Classes:
G01N33/574; C12N15/10; G01N27/62
Domestic Patent References:
| JP2015500478A | ||||
| JP2014531573A | ||||
| JP2014529405A |
Foreign References:
| US20130230858 | ||||
| WO2005019826A1 | ||||
| WO2013030578A2 |
Other References:
Jun Sakamoto,Immunoprecipitation of nucleosomal DNA is a novel procedure to improve the sensitivity of serum screening for the p16 hypermethylation associated with colon cancer,Cancer Epidemiology,2010年,Vol.34,Page.194-199
Hye Ryung Jung,Quantitative Mass Spectrometry of Histones H3.2 and H3.3 in Suz12-deficient Mouse Embryonic Stem Cells Reveals Distinct, Dynamic Post-translational Modifications at Lys-27 and Lys-36,Molecular & Cellular Proteomics,2010年 5月 1日,Vol.9 No.5,Page.838-850
Jakub Karczmarski,Histone H3 lysine 27 acetylation is altered in colon cancer,Clinical Proteomics,2014年,Page.11:24
Andreas Lennartsson,Histone modification patterns and epigenetic codes,Biochimica et Biophysica Acta (BBA) - General Subjects,2009年 9月,Vol.1790 No.9,Page.863-868
Hye Ryung Jung,Quantitative Mass Spectrometry of Histones H3.2 and H3.3 in Suz12-deficient Mouse Embryonic Stem Cells Reveals Distinct, Dynamic Post-translational Modifications at Lys-27 and Lys-36,Molecular & Cellular Proteomics,2010年 5月 1日,Vol.9 No.5,Page.838-850
Jakub Karczmarski,Histone H3 lysine 27 acetylation is altered in colon cancer,Clinical Proteomics,2014年,Page.11:24
Andreas Lennartsson,Histone modification patterns and epigenetic codes,Biochimica et Biophysica Acta (BBA) - General Subjects,2009年 9月,Vol.1790 No.9,Page.863-868
Attorney, Agent or Firm:
Toru Ishikawa