Title:
免疫療法のための調節粒子
Document Type and Number:
Japanese Patent JP6845691
Kind Code:
B2
Abstract:
Nanoparticulate compositions are disclosed. The nanoparticulate compositions typically include at least one, preferably two or more, active agent(s), one of which is an immunomodulatory compound, loaded into, attached to the surface of and/or enclosed within a delivery vehicle. The delivery vehicles can be nanolipogels including a polymeric core and a lipid shell or a biodegradable polymeric nanoparticle such as a PLGA nanoparticle. Typically, at least one of the active agents is an immunomodulator that increases an immune stimulatory response or decreases an immune suppressive response. In some embodiments, the particle includes both an immunomodulator that increases an immune stimulatory response and an immunomodulator that decreases an immune suppressive response. The particles can be decorated with a targeting moiety that improves delivery to a target cell. Methods of using the compositions to enhance an immune response and treat diseases such as cancer are also disclosed.
Inventors:
Farmy, tarek
Horsburgh, Brian
Horsburgh, Brian
Application Number:
JP2016527304A
Publication Date:
March 24, 2021
Filing Date:
October 31, 2014
Export Citation:
Assignee:
Yale University
International Classes:
A61K38/20; A61K9/127; A61K9/51; A61K31/4439; A61K47/34; A61P35/00; A61P37/02
Domestic Patent References:
JP2008512350A | ||||
JP2012505245A | ||||
JP2013067632A |
Foreign References:
WO2013155487A1 | ||||
WO2012153286A1 | ||||
WO2012068531A1 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita