Title:
ヒト無調ホモログ−１（ＨＡＴＨ１）をコードするアデノウイルスベクター
Document Type and Number:
Japanese Patent JP6863890
Kind Code:
B2
Abstract:
The invention is directed to a replication-deficient adenoviral vector comprising a nucleic acid sequence encoding a human atonal homolog-1 (Hath1) protein operably linked to a human glial fibrillary acidic protein (GFAP) promoter. The invention also is directed to a composition and method utilizing the adenoviral vector to generate sensory cells in the inner ear of a human.
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Inventors:
Bluff, Douglas E.
Etty Lady, Damauder Earl.
Etty Lady, Damauder Earl.
Application Number:
JP2017518815A
Publication Date:
April 21, 2021
Filing Date:
October 09, 2015
Export Citation:
Assignee:
Genvec LRC
International Classes:
C12N15/861; A61K35/761; A61K48/00; A61P27/16
Domestic Patent References:
| JP2006516027A | ||||
| JP2011062204A | ||||
| JP11502421A | ||||
| JP2002330786A |
Other References:
Acta Otolaryngol.,2010年,Vol. 130, No. 2,pp. 215-222
Gene Therapy,2011年,Vol. 18,pp. 884-890
Cellular Reprogramming,2013年,Vol. 15, No. 1,pp. 43-54
J. Virol.,2002年,Vol. 76, No. 8,pp. 3670-3677
Gene Therapy,2011年,Vol. 18,pp. 884-890
Cellular Reprogramming,2013年,Vol. 15, No. 1,pp. 43-54
J. Virol.,2002年,Vol. 76, No. 8,pp. 3670-3677
Attorney, Agent or Firm:
Hiroshi Kobayashi
Norio Omori
Koichi Iwata
Yasuhito Suzuki
Norio Omori
Koichi Iwata
Yasuhito Suzuki