Title:
陽イオン性神経毒
Document Type and Number:
Japanese Patent JP6867452
Kind Code:
B2
Abstract:
To provide engineered clostridial toxins comprising at least one amino acid modification, and to provide methods of using such engineered clostridial toxins in medicine and therapy.SOLUTION: There is provided an engineered clostridial toxin comprising at least one amino acid modification, the at least one amino acid modification increasing the isoelectric point (pI) of the engineered clostridial toxin to a value that is at least 0.2 pI units higher than the pI of an otherwise identical clostridial toxin lacking the at least one amino acid modification, and the at least one amino acid modification being not located in the clostridial toxin binding domain (HC domain).SELECTED DRAWING: Figure 2
Inventors:
Anderson, Dina Brady
Hackett, Gavin Stephen
Liu, Cyman
Hackett, Gavin Stephen
Liu, Cyman
Application Number:
JP2019147451A
Publication Date:
April 28, 2021
Filing Date:
August 09, 2019
Export Citation:
Assignee:
Ibsen Bio Innovation Limited
International Classes:
C07K14/33; A61K38/16; A61P21/02; C12N15/31; C12P21/02
Domestic Patent References:
| JP2004536778A | ||||
| JP2013517797A | ||||
| JP2007511609A |
Foreign References:
| WO1996039166A1 |
Attorney, Agent or Firm:
Patent Business Corporation Moegi Patent Office