Title:
不可逆的に阻害されたＣＹＰ４５０ミクロソーム、及び代謝経路の酵素の表現型決定におけるその使用
Document Type and Number:
Japanese Patent JP6869721
Kind Code:
B2
Abstract:
A method of preparing isolated microsomes comprising an irreversibly inhibited cytochrome P450 (CYP450). Isolated microsomes are characterized in that a cytochrome P450 thereof is irreversibly inhibited by a non-reversible inhibitor. The isolated microsomes according to the invention may be used in a method of phenotyping enzymatic reactions of a drug candidate.
Inventors:
Karadek, Fabrice
Palmantie, Janic
Collier, Potier
Palmantie, Janic
Collier, Potier
Application Number:
JP2016536753A
Publication Date:
May 12, 2021
Filing Date:
December 05, 2014
Export Citation:
Assignee:
Réra Bora Toir Servier
International Classes:
C12N5/071; C12Q1/02; C12Q1/24
Other References:
Chemico-Biological Interactions, 2012, vol.198, no.1, p.49-56
Drug Metab Dispos, 2004, vol.32, no.1, p.105-112
Br J Clin Pharmacol, 1998, vol.45, no.2, p.107-114
Br J Clin Pharmacol, 1999, vol.47, no.3, p.299-305
Drug Metab Dispos, 2004, vol.32, no.1, p.105-112
Br J Clin Pharmacol, 1998, vol.45, no.2, p.107-114
Br J Clin Pharmacol, 1999, vol.47, no.3, p.299-305
Attorney, Agent or Firm:
Patent business corporation Tsukuni