Title:
ＮＲ２ＢＮＭＤＡレセプターアンタゴニストとしての３，３−ジフルオロピペリジンカルバメート複素環式化合物
Document Type and Number:
Japanese Patent JP6876625
Kind Code:
B2
Abstract:
Disclosed are chemical entities of Formula (I), wherein R1 and Z are defined herein, as NR2B subtype selective receptor antagonists. Also disclosed are pharmaceutical compositions comprising a chemical entity of Formula (I), and methods of treating various diseases and disorders associated with NR2B antagonism, e.g., diseases and disorders of the CNS, such as depression, by administering a chemical entity of Formula (I).
Inventors:
Shapiro, Gideon
Application Number:
JP2017562029A
Publication Date:
May 26, 2021
Filing Date:
May 31, 2016
Export Citation:
Assignee:
Rügen Holdings (Cayman) Limited
International Classes:
C07D401/12; A61K31/506; A61P25/00; A61P25/04; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/24; A61P25/28; A61P43/00
Domestic Patent References:
| JP2004524314A | ||||
| JP2006526650A | ||||
| JP2010502704A |
Foreign References:
| WO2015069593A1 | ||||
| WO2014092100A1 |
Other References:
PATANI, G. A. et al.,Chmeical Review ,1996年,Vol. 96,pp. 3147-3176
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
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