Title:
オーバーサイズアデノ随伴ベクターの産生
Document Type and Number:
Japanese Patent JP6878299
Kind Code:
B2
Abstract:
Provided herein are methods for producing an adeno-associated virus (AAV) particle containing an oversized recombinant AAV genome (e.g., greater than 4.7 kb). In some aspects, the invention provides AAV particles and AAV vectors comprising oversized rAAV genomes. Producer cell lines to produce AAV particles comprising oversized genomes are also provided.
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Inventors:
Sirkka Kyostio-Moore
David Souza
Karen Vincent
David Souza
Karen Vincent
Application Number:
JP2017553005A
Publication Date:
May 26, 2021
Filing Date:
April 07, 2016
Export Citation:
Assignee:
GENZYME CORPORATION
International Classes:
C12N15/864; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N7/01
Foreign References:
| WO2015038625A1 | ||||
| WO2014064277A1 |
Other References:
ZHENHUA YUAN ; ET AL,A VERSATILE ADENO-ASSOCIATED VIRUS VECTOR PRODUCER CELL LINE METHOD FOR SCALABLE VECTOR PRODUCTION OF DIFFERENT SEROTYPES,HUMAN GENE THERAPY,米国,2011年 5月,V22 N5,P613-624,URL,https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081441/
LU H ; ET AL,COMPLETE CORRECTION OF HEMOPHILIA A WITH ADENO-ASSOCIATED VIRAL VECTORS CONTAINING A FULL-SIZE EXPRESSION CASSETTE,HUMAN GENE THERAPY,米国,2008年 6月,V19 N6,P648-654,URL,https://www.ncbi.nlm.nih.gov/pubmed/18500941
LU H ; ET AL,COMPLETE CORRECTION OF HEMOPHILIA A WITH ADENO-ASSOCIATED VIRAL VECTORS CONTAINING A FULL-SIZE EXPRESSION CASSETTE,HUMAN GENE THERAPY,米国,2008年 6月,V19 N6,P648-654,URL,https://www.ncbi.nlm.nih.gov/pubmed/18500941
Attorney, Agent or Firm:
Junji Yuda
Noriyuki Takebayashi
Noriyuki Takebayashi