Title:
ヒトＩＬ−３４を有する非ヒト動物及びその使用
Document Type and Number:
Japanese Patent JP6886524
Kind Code:
B2
Abstract:
The present invention provides a non-human animal having human interleukin-34 (IL-34) in the body thereof; a method for producing a non-human animal having human microglia, which includes transplanting human CD34-positive hematopoietic stem cells into the non-human animal having human IL-34 in the body; and a method for producing human microglia, which includes obtaining human microglia from the non-human animal having human microglia.
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Inventors:
Prutowararisa
Golantra Santi
Mamoru Ito
Ikumi Katano
Golantra Santi
Mamoru Ito
Ikumi Katano
Application Number:
JP2019544759A
Publication Date:
June 16, 2021
Filing Date:
March 18, 2019
Export Citation:
Assignee:
Central Institute for Experimental Animals
International Classes:
A01K67/027; C12N5/0786
Other References:
WEI, Suwen et al,Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells,JOURNAL OF LEUKOCYTE BIOLOGY,2010年 5月26日,Vol.88, No.3,pp.495-505
ASHEUER, Muriel et al,Human CD34+ cells differentiate into microglia and express recombinant therapeutic protein,Proceedings of the National Academy of Sciences of the United States of America,米国,2004年 3月 9日,Vol.101, No.10,pp.3557-3562
DASH, Prasanta K. et al,Loss of Neuronal Integrity during Progressive HIV-1 Infection of Humanized Mice,The Journal of Neuroscience,2011年 3月 2日,Vol.31, No.9,pp.3148-3157
錫村 明生 ,免疫性神経疾患の病態とミクログリア Microglia in neuroimmunological disorders,日本臨床(別冊) 免疫性神経疾患 Vol.73,Suppl.7,瓦谷 秀治 株式会社日本臨牀社,第73巻
PAQUIN-PROULX, Dominic et al,Human interleukin-34-derived macrophages have increased resistance to HIV-1 infection,Cytokine,2018年 9月19日,Vol.111,pp.272-277
YANG, Qing et al,The Establishment of Interleukin 34 Transgenic mice,CHINESE JOURNAL OF COMPARATIVE MEDICINE,中国,2011年 6月,Vol.21, No.6,pp.64-66, 59,特にAbstract
ASHEUER, Muriel et al,Human CD34+ cells differentiate into microglia and express recombinant therapeutic protein,Proceedings of the National Academy of Sciences of the United States of America,米国,2004年 3月 9日,Vol.101, No.10,pp.3557-3562
DASH, Prasanta K. et al,Loss of Neuronal Integrity during Progressive HIV-1 Infection of Humanized Mice,The Journal of Neuroscience,2011年 3月 2日,Vol.31, No.9,pp.3148-3157
錫村 明生 ,免疫性神経疾患の病態とミクログリア Microglia in neuroimmunological disorders,日本臨床(別冊) 免疫性神経疾患 Vol.73,Suppl.7,瓦谷 秀治 株式会社日本臨牀社,第73巻
PAQUIN-PROULX, Dominic et al,Human interleukin-34-derived macrophages have increased resistance to HIV-1 infection,Cytokine,2018年 9月19日,Vol.111,pp.272-277
YANG, Qing et al,The Establishment of Interleukin 34 Transgenic mice,CHINESE JOURNAL OF COMPARATIVE MEDICINE,中国,2011年 6月,Vol.21, No.6,pp.64-66, 59,特にAbstract
Attorney, Agent or Firm:
Field Saki Satoshi
Junichi Kobayashi
Yuichiro Kawagoe
Hirotaka Haruta
Junichi Kobayashi
Yuichiro Kawagoe
Hirotaka Haruta