Title:
エクソソーム分泌阻害剤
Document Type and Number:
Japanese Patent JP6895175
Kind Code:
B2
Abstract:
An exosome secretion inhibitor containing a substance suppressing expression of NAPG, HINT3 or GXYLT1 gene, or a substance suppressing activity of NAPG, HINT3 or GXYLT1 protein. It is possible to suppress secretion of exosome, thereby making it possible to suppress proliferation or metastasis of cancer cells, so that the substance suppressing expression of the gene or activity of the protein can be used as an active ingredient of a pharmaceutical composition suitably used in treatment of cancer or suppression of cancer metastasis, and also the substance can provide a carcinostatic agent having a new action mechanism which specifically suppresses expression of the gene or activity of the protein.
Inventors:
Takahiro Ochiya
Yusuke Yoshioka
Nozomi Kosaka
Yusuke Yoshioka
Nozomi Kosaka
Application Number:
JP2017539125A
Publication Date:
June 30, 2021
Filing Date:
August 30, 2016
Export Citation:
Assignee:
Theoria Science inc.
International Classes:
A61K31/713; A61K31/7088; A61K31/7105; A61K48/00; A61P15/00; A61P35/00; A61P35/04; A61P43/00; C12Q1/04
Domestic Patent References:
| JP2012125247A |
Other References:
HAN, K., et al.,microRNA-194 suppresses osteosarcoma cell proliferation and metastasis in vitro and in vivo by targe,Int. J. Oncology, 2014, Vol.45, pp.1437-1449,Abstract、第1437頁右欄最終段落-第1438頁左欄第2段落、第1443左欄第2段落-第1444頁最終行、Fig.7
MENG, Z., et al.,miR-194 is a marker of hepatic epithelial cells and suppresses metastasis of liver cancer cells in m,Hepatology, 2010, Vol.52, pp.2148-2157,Abstract
KHELLA, HW., et al.,miR-192, miR-194 and miR-215: a convergent microRNA network suppressing tumor progression in renal c,Carcinogenesis, 2013, Vol.34, No.10, pp.2231-2239,Abstract、Fig.1
MENG, Z., et al.,miR-194 is a marker of hepatic epithelial cells and suppresses metastasis of liver cancer cells in m,Hepatology, 2010, Vol.52, pp.2148-2157,Abstract
KHELLA, HW., et al.,miR-192, miR-194 and miR-215: a convergent microRNA network suppressing tumor progression in renal c,Carcinogenesis, 2013, Vol.34, No.10, pp.2231-2239,Abstract、Fig.1
Attorney, Agent or Firm:
Yumi Nakayama